Publication Name	World Journal of Transplantation
Manuscript ID	66854
Country	United States

Received	2021-04-07 16:58
Peer-Review Started	2021-04-07 17:01
To Make the First Decision
Return for Revision	2021-07-08 07:23
Revised	2021-07-19 19:45
Second Decision	2021-08-26 03:28
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-08-27 10:37
Articles in Press	2021-08-27 10:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-09-13 04:32
Publish the Manuscript Online	2021-09-15 06:29

ISSN	2220-3230 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Transplantation
Manuscript Type	Review
Article Title	Voriconazole-associated periostitis: Pathophysiology, risk factors, clinical manifestations, diagnosis, and management
Manuscript Source	Invited Manuscript
All Author List	Anthony J Guarascio, Nitin Bhanot and Zaw Min
ORCID	Author(s) ORCID Number Anthony J Guarascio http://orcid.org/0000-0001-9019-8847 Nitin Bhanot http://orcid.org/0000-0002-9505-0910 Zaw Min http://orcid.org/0000-0002-5708-954X
Funding Agency and Grant Number
Corresponding Author	Zaw Min, MD, Assistant Professor, Division of Infectious Disease, Medicine Institute, Allegheny General Hospital, Allegheny Health Network, 420 East North Avenue, Suite 407, Pittsburgh, PA 15212, United States. zaw.min@ahn.org
Key Words	Voriconazole; Periostitis; Fluoride; Fluorosis; Alkaline phosphatase
Core Tip	Voriconazole-induced periostitis is rare, and typically presents as bone pain following months of voriconazole treatment. Fluoride, present in voriconazole, deposits within the bony matrix causing bone pains and high serum alkaline phosphatase (ALP) with or without elevated plasma fluoride level. Evidence of periostitis is typically observed on skeletal imaging. Symptom relief occurs shortly after discontinuation of voriconazole, and normalization of serum ALP occurs in the following weeks to months. We herein discuss the pathophysiology and diagnosis of voriconazole-induced periostitis, its prevalence in different patient populations, and clinical outcomes.
Publish Date	2021-09-15 06:29
Citation	Guarascio AJ, Bhanot N, Min Z. Voriconazole-associated periostitis: Pathophysiology, risk factors, clinical manifestations, diagnosis, and management. World J Transplant 2021; 11(9): 356-371
URL	https://www.wjgnet.com/2220-3230/full/v11/i9/356.htm
DOI	https://dx.doi.org/10.5500/wjt.v11.i9.356

Full Article (PDF)	WJT-11-356.pdf
Full Article (Word)	WJT-11-356.docx
Manuscript File	66854_Auto_Edited-JLW.docx
Answering Reviewers	66854-Answering reviewers.pdf
Audio Core Tip	66854-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	66854-Conflict-of-interest statement.pdf
Copyright License Agreement	66854-Copyright license agreement.pdf
Peer-review Report	66854-Peer-review(s).pdf
Scientific Misconduct Check	66854-Scientific misconduct check.pdf
Scientific Editor Work List	66854-Scientific editor work list.pdf
CrossCheck Report	66854-CrossCheck report.pdf