Publication Name	World Journal of Gastroenterology
Manuscript ID	6687
Country	Hungary

Received	2013-10-31 19:05
Peer-Review Started	2013-11-01 15:57
To Make the First Decision	2014-01-09 12:23
Return for Revision	2014-01-11 20:18
Revised	2014-01-26 14:57
Second Decision	2014-05-26 16:19
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-05-26 16:39
Articles in Press	2014-05-26 17:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-09-10 11:14
Publish the Manuscript Online	2014-10-07 17:32

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Impact of proteolytic enzymes in colorectal cancer development and progression
Manuscript Source	Invited Manuscript
All Author List	László Herszényi, Loránd Barabás, István Hritz, Gábor István and Zsolt Tulassay
Funding Agency and Grant Number
Corresponding Author	László Herszényi, MD, DSc, 2nd Department of Medicine, Semmelweis University, Szentkirályi str. 46, H-1088 Budapest, Hungary. herszenyi.laszlo@med.semmelweis-univ.hu
Key Words	Proteinase; Cathepsin; Plasminogen activator; Matrix metalloproteinase; Colorectal cancer; Adenoma; Invasion; Metastasis; Biomarker; Prognosis
Core Tip	Tumor invasion and metastasis is a highly complex phenomenon. Proteolytic enzymes (proteinases) are involved in the degradation of extracellular matrix, in colorectal cancer (CRC) invasion and metastasis, as well as in the malignant transformation of colorectal adenomas. Tissue and serum-plasma antigen concentrations of proteinases are strong prognostic factors in CRC and may have tumor marker impact for early diagnosis. Proteolytic enzymes may serve as potential target molecules for CRC therapy. Their use in combination with established chemotherapeutic strategies might have the potential to become a valuable oncological treatment modality.
Publish Date	2014-10-07 17:32
Citation	ényi L, Barabás L, Hritz I, István G, Tulassay Z. Impact of proteolytic enzymes in colorectal cancer development and progression. World J Gastroenterol 2014; 20(37): 13246-13257
URL	http://www.wjgnet.com/1007-9327/full/v20/i37/13246.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i37.13246

Full Article (PDF)	WJG-20-13246.pdf
Full Article (Word)	WJG-20-13246.doc
Manuscript File	6687-Review.doc
Answering Reviewers	6687-Answering reviewers.pdf
Copyright License Agreement	6687-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	6687-Language certificate.pdf
Peer-review Report	6687-Peer review(s).pdf
Scientific Misconduct Check	6687-CrossCheck.jpg
Scientific Editor Work List	6687-Scientific editor work list.pdf