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Articles Published Processes
5/24/2022 12:41:49 PM | Browse: 419 | Download: 1051
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Received |
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2021-04-09 01:27 |
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Peer-Review Started |
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2021-04-09 01:29 |
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To Make the First Decision |
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Return for Revision |
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2021-06-28 08:45 |
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Revised |
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2021-07-06 21:55 |
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Second Decision |
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2022-04-22 02:15 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-04-22 19:21 |
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Articles in Press |
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2022-04-22 19:21 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-05-13 07:14 |
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Publish the Manuscript Online |
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2022-05-24 12:41 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Tumor specifically internalizing peptide ‘HN-1’: Targeting the putative receptor retinoblastoma-regulated discoidin domain receptor 1 involved in metastasis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Frank-Un Hong, Miguel Castro and Klaus Linse |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Frank-Un Hong, PhD, Research Scientist, Research & Development, Bio-Synthesis, Inc., 612 E Main St, Lewisville, TX 75057, United States. frank_hong@biosyn.com |
| Key Words |
HN-1 peptide; Solid tumor; Targeted drug delivery; Discoidin domain receptor 1; Tyrosine kinase; Metastasis |
| Core Tip |
The side effects associated with current drugs are exacerbated by the accumulation of administered drugs in non-tumor tissues. To guide, various tumor-homing vectors have been developed though their delivery efficacy is limited by poor penetration into solid tumors. To resolve, the ‘tumor specifically internalizing peptide’ HN-1 was isolated via biopanning a phage-display library. HN-1 peptide targets human head and neck squamous cell carcinoma (breast, thyroid, potentially cervical, lung, uterine, colon cancer), translocates across the cell membrane and effectively penetrates solid tumors. Here, deciphering of the clues that pointed to discoidin domain receptor 1 as the putative receptor for HN-1 is described. |
| Publish Date |
2022-05-24 12:41 |
| Citation |
Hong FU, Castro M, Linse K. Tumor specifically internalizing peptide ‘HN-1’: Targeting the putative receptor retinoblastoma-regulated discoidin domain receptor 1 involved in metastasis. World J Clin Oncol 2022; 13(5): 323-338 |
| URL |
https://www.wjgnet.com/2218-4333/full/v13/i5/323.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v13.i5.323 |
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