Publication Name	World Journal of Gastroenterology
Manuscript ID	6692
Country	Japan

Received	2013-10-27 11:05
Peer-Review Started	2013-10-28 11:55
To Make the First Decision	2013-11-13 15:35
Return for Revision	2013-11-14 16:22
Revised	2013-11-22 15:52
Second Decision	2014-01-08 18:15
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-01-08 18:37
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-02-26 14:46
Publish the Manuscript Online	2014-03-12 14:46

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Immunology
Manuscript Type	Topic Highlights
Article Title	Autoantibodies in primary biliary cirrhosis: Recent progress in research on the pathogenetic and clinical significance
Manuscript Source	Invited Manuscript
All Author List	Satoshi Yamagiwa, Hiroteru Kamimura, Masaaki Takamura and Yutaka Aoyagi
Funding Agency and Grant Number
Corresponding Author	Satoshi Yamagiwa, MD, PhD, Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, 757 Asahimachi-dori 1, Chuo-ku, Niigata 951-8510, Japan. syamagi@med.niigata-u.ac.jp
Key Words	Primary biliary cirrhosis; Autoantibodies; Anti-mitochondrial antibodies; Anticentromere antibodies; Anti-gp210 antibodies.
Core Tip	While the presence of antimitochondrial antibodies is pathognomonic to Primary biliary cirrhosis (PBC), more than 60 autoantibodies have been detected in patients with PBC. Antinuclear antibodies (ANA) become positive in approximately 30% to 50% of patients with PBC. Among ANA, anti-gp210 and anticentromere antibodies have been indicated as significant prognostic markers. Previous studies have shown that unique characteristics of biliary epithelial cells during apoptosis may result in the presence of a direct and specific immune response to mitochondrial autoantigens. Moreover, recent studies have indicated that chemicals originating from the environment are associated with a breakdown in the tolerance against mitochondrial autoantigens.
Publish Date	2014-03-12 14:46
Citation	Yamagiwa S, Kamimura H, Takamura M, Aoyagi Y. Autoantibodies in primary biliary cirrhosis: Recent progress in research on the pathogenetic and clinical significance. World J Gastroenterol 2014; 20(10): 2606-2612
URL	http://www.wjgnet.com/1007-9327/full/v20/i10/2606.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i10.2606

Full Article (PDF)	WJG-20-2606.pdf
Full Article (Word)	WJG-20-2606.doc
Manuscript File	6692-Review.docx
Answering Reviewers	6692-Answering reviewers.pdf
Copyright License Agreement	6692-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	6692-Language certificate.pdf
Peer-review Report	6692-Peer review(s).pdf
Scientific Editor Work List	6692-Scientific editor work list.doc