Publication Name	World Journal of Gastroenterology
Manuscript ID	66941
Country	United Kingdom

Received	2021-04-09 20:22
Peer-Review Started	2021-04-09 20:26
To Make the First Decision	2021-05-17 07:39
Return for Revision	2021-05-17 07:40
Revised	2021-05-18 19:48
Second Decision	2022-02-17 05:50
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-02-20 12:37
Articles in Press	2022-02-20 12:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-03-08 21:49
Publish the Manuscript Online	2022-03-17 03:25

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Review
Article Title	B cells in pancreatic cancer stroma
Manuscript Source	Invited Manuscript
All Author List	Francesca Romana Delvecchio, Michelle R Goulart, Rachel Elizabeth Ann Fincham, Michele Bombadieri and Hemant M Kocher
ORCID	Author(s) ORCID Number Francesca Romana Delvecchio http://orcid.org/0000-0002-3661-1212 Michelle R Goulart http://orcid.org/0000-0001-8333-3908 Rachel Elizabeth Ann Fincham http://orcid.org/0000-0002-4699-5002 Michele Bombadieri http://orcid.org/0000-0002-3878-5216 Hemant M Kocher http://orcid.org/0000-0001-6771-1905
Funding Agency and Grant Number
Corresponding Author	Hemant M Kocher, FRCS (Gen Surg), MBBS, MD, MS, Professor, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, United Kingdom. h.kocher@qmul.ac.uk
Key Words	B cells; Pancreatic cancer; Cancer immunology; Tertiary lymphoid structures; Anti-tumour immunoglobulins; Plasma cells
Core Tip	The role of B cells in pancreatic ductal adenocarcinoma tumorigenesis is controversial. Human studies show clusters of B cells, interacting with other immune cells, forming active sites of the immune response, called tertiary lymphoid structures. In vitro experiments and in vivo studies using B-cell deficient mice suggest the role of an immuno-suppressive B cell phenotype to induce tumour-progression. These discordant findings highlight the need of further studies using better murine models to recapitulate pancreatic cancer and its immune infiltrate.
Publish Date	2022-03-17 03:25
Citation	Delvecchio FR, Goulart MR, Fincham REA, Bombadieri M, Kocher HM. B cells in pancreatic cancer stroma. World J Gastroenterol 2022; 28(11): 1088-1101
URL	https://www.wjgnet.com/1007-9327/full/v28/i11/1088.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i11.1088

Full Article (PDF)	WJG-28-1088.pdf
Full Article (Word)	WJG-28-1088.docx
Manuscript File	66941_Auto_Edited.docx
Answering Reviewers	66941-Answering reviewers.pdf
Audio Core Tip	66941-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	66941-Conflict-of-interest statement.pdf
Copyright License Agreement	66941-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	66941-Grant application form(s).pdf
Peer-review Report	66941-Peer-review(s).pdf
Scientific Misconduct Check	66941-Bing-Chang KL-2.jpg
Scientific Editor Work List	66941-Scientific editor work list.pdf
CrossCheck Report	66941-CrossCheck report.pdf