Publication Name	World Journal of Hematology
Manuscript ID	6702
Country	United States

Received	2013-10-27 11:44
Peer-Review Started	2013-10-28 13:34
To Make the First Decision	2014-01-16 08:24
Return for Revision	2014-01-20 17:56
Revised	2014-02-15 03:10
Second Decision	2014-06-18 15:08
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-06-18 15:28
Articles in Press	2014-06-18 15:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-09-28 17:47
Publish the Manuscript Online	2014-10-20 10:04

ISSN	2218-6204 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Hematology
Manuscript Type	Autobiography
Article Title	Tbl3 encodes a WD40 nucleolar protein with regulatory roles in ribosome biogenesis
Manuscript Source	Invited Manuscript
All Author List	Jindong Wang and Schickwann Tsai
Funding Agency and Grant Number	Funding Agency Grant Number St. Perres Fund 11-02011
Corresponding Author	Schickwann Tsai, MD PhD Department of Internal Medicine University of Utah 30 North 1900 East, 5C402 Salt Lake City, Utah 84132 U.S.A. schickwann.tsai@hsc.utah.edu
Key Words	nucleolus; nucleolar protein; ribosome biogenesis; ribosomal RNA; pre-ribosomal RNA
Core Tip	The mouse gene transducin β-like 3 (Tbl3) encodes a protein with thirteen WD40 protein-protein interaction motifs and is the mammalian homologue of yeast utp13. Virtually nothing is known about the function of tbl3. In this report, we provide the first direct evidence that tbl3 is targeted to the nucleoli and plays an important role in regulating the synthesis of the 47S pre-rRNA, i.e. at very early stages of ribosome biogenesis. This activity has never been described before and sets tbl3 apart from all other known nucleolar proteins. TBL3 may provide an attractive target for anti-neoplastic therapy.
Publish Date	2014-10-20 10:04
Citation	Wang J, Tsai S. Tbl3 encodes a WD40 nucleolar protein with regulatory roles in ribosome biogenesis. World J Hematol 2014; 3(3): 93-104
URL	http://www.wjgnet.com/2218-6204/full/v3/i3/93.htm
DOI	http://dx.doi.org/10.5315/wjh.v3.i3.93

Full Article (PDF)	WJH-3-93.pdf
Full Article (Word)	WJH-3-93.doc
Manuscript File	6702-Review.doc
Answering Reviewers	6702-Answering reviewers.pdf
Biostatistics Review Certificate	Biostatistician_Review_Report_20131027034924.docx
Copyright License Agreement	6702-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20131027034848.docx
Non-Native Speakers of English Editing Certificate	Editing_Certificate_20131027035145.docx
Peer-review Report	6702-Peer reviews.pdf
Scientific Misconduct Check	6702-CrossCheck.jpg
Scientific Editor Work List	6702-Scientific editor work list.pdf