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Articles Published Processes
10/26/2021 3:59:25 AM | Browse: 447 | Download: 973
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Received |
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2021-04-13 10:34 |
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Peer-Review Started |
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2021-04-13 10:36 |
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To Make the First Decision |
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Return for Revision |
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2021-05-12 02:02 |
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Revised |
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2021-05-25 18:11 |
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Second Decision |
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2021-09-18 03:29 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-09-19 09:07 |
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Articles in Press |
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2021-09-19 09:07 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-10-22 08:37 |
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Publish the Manuscript Online |
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2021-10-26 03:59 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Effect of glycyrrhizic acid and 18β-glycyrrhetinic acid on the differentiation of human umbilical cord-mesenchymal stem cells into hepatocytes
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Abiha Fatima, Tuba Shakil Malick, Irfan Khan, Aisha Ishaque and Asmat Salim |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Asmat Salim, PhD, Professor, Stem Cell Laboratory, Dr. Panjwani Center for Molecular Medicine and Drug Research, ICCBS, University of Karachi, NA, Karachi 75270, Sindh, Pakistan. asmat.salim@iccs.edu |
| Key Words |
Glycyrrhizic acid; 18β-glycyrrhetinic acid; Hepatocyte differentiation; Human umbilical cord-MSCs; Mesenchymal stem cells |
| Core Tip |
This study focuses on exploring the effect of two triterpenes, glycyrrhizic acid and 18β-glycyrrhetinic acid to enhance the differentiation potential of mesenchymal stem cells (MSCs) into hepatocytes to ensure a potent and valuable cell source for cellular therapy for end-stage liver disease. Preconditioning of human umbilical cord-MSCs with these compounds enhances expression of both early and late hepatic markers, regulated with time of differentiation. The significant expression of hepatocyte markers, the ability to store glycogen, and presence of bi-nucleated cells, suggest successful hepatic differentiation. Preconditioned MSCs may help in the replacement of damaged hepatocytes, and improve liver function post-transplantation in impaired hepatic tissues. |
| Publish Date |
2021-10-26 03:59 |
| Citation |
Fatima A, Malick TS, Khan I, Ishaque A, Salim A. Effect of glycyrrhizic acid and 18β-glycyrrhetinic acid on the differentiation of human umbilical cord-mesenchymal stem cells into hepatocytes. World J Stem Cells 2021; 13(10): 1580-1594 |
| URL |
https://www.wjgnet.com/1948-0210/full/v13/i10/1580.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v13.i10.1580 |
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