Publication Name	World Journal of Clinical Cases
Manuscript ID	67072
Country	China

Received	2021-04-26 08:55
Peer-Review Started	2021-04-26 08:58
To Make the First Decision
Return for Revision	2021-05-31 02:20
Revised	2021-06-14 16:11
Second Decision	2021-08-24 03:19
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-08-24 09:41
Articles in Press	2021-08-24 09:41
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-11-30 17:34
Typeset the Manuscript	2021-12-24 09:13
Publish the Manuscript Online	2021-12-30 08:21

ISSN	2307-8960 (online)
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Category	Biochemistry & Molecular Biology
Manuscript Type	Minireviews
Article Title	Paradox role of interleukin-33/suppressor of tumorigenicity 2 in colorectal carcinogenesis, progress and therapeutic potential
Manuscript Source	Unsolicited Manuscript
All Author List	Fang Huang, Wan-Yuan Chen, Jie Ma, Xiang-Lei He and Jian-Wei Wang
ORCID	Author(s) ORCID Number Fang Huang http://orcid.org/0000-0002-3115-8703 Wan-Yuan Chen http://orcid.org/0000-0002-8216-9568 Jie Ma http://orcid.org/0000-0003-3755-996X Xiang-Lei He http://orcid.org/0000-0002-2559-0049 Jian-Wei Wang http://orcid.org/0000-0003-1671-4780
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of China 81803069 Zhejiang Medical Technology Plan Project 2019RC007 Zhejiang Medical Technology Plan Project 2019KY007 Zhejiang Medical Technology Plan Project 2021KY047 Funds of Science Technology Department of Zhejiang Province LGF21H160033
Corresponding Author	Jian-Wei Wang, MD, Assistant Professor, Department of Pathology, Laboratory Medicine Center, Zhejiang Provincial Peoples’ Hospital, Peoples’ Hospital of Hangzhou Medical College, No. 158 Shangtang Road, Hangzhou 310014, Zhejiang Province, China. wangjianwei2002@126.com
Key Words	Interleukin 33; Suppressor of tumorigenicity 2 signaling; Tumor microenvironment; Conventional therapies; Colorectal cancer
Core Tip	Interleukin-33 (IL-33) belongs to the IL-1 cytokine family and binds to the suppressor of tumorigenicity 2 (ST2) receptor. IL-33 plays a key role in cancer progression due to interact with cellular components in the inflammatory microenvironment of tumors. Therefore, it is a challenge to design and optimize treatment strategies suitable for colorectal cancer (CRC) based on IL-33/ST2 signal to coordinate tumor microenvironment. IL-33 also has effects on CRC prevention. These findings implicated multifaceted roles of IL-33 in cancer treatment.
Publish Date	2021-12-30 08:21
Citation	Huang F, Chen WY, Ma J, he X, Wang J. Paradox role of interleukin-33/suppressor of tumorigenicity 2 in colorectal carcinogenesis, progress and therapeutic potential. World J Clin Cases 2022; 10(1): 23-34
URL	https://www.wjgnet.com/2307-8960/full/v10/i1/23.htm
DOI	https://dx.doi.org/10.12998/wjcc.v10.i1.23

Full Article (PDF)	WJCC-10-23.pdf
Full Article (Word)	WJCC-10-23.docx
Manuscript File	67072_Auto_Edited-JLW_Kerr C_Clear Copy.docx
Answering Reviewers	67072-Answering reviewers.pdf
Audio Core Tip	67072-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	67072-Conflict-of-interest_statement.pdf
Copyright License Agreement	67072-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	67072-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	67072-Language certificate.pdf
Peer-review Report	67072-Peer-review(s).pdf
Scientific Misconduct Check	67072-Scientific misconduct check.pdf
Scientific Editor Work List	67072-Scientific editor work list.pdf