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Articles Published Processes
1/20/2022 10:47:59 AM | Browse: 213 | Download: 552
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Received |
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2021-04-18 20:19 |
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Peer-Review Started |
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2021-04-18 20:22 |
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To Make the First Decision |
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Return for Revision |
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2021-05-12 01:58 |
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Revised |
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2021-05-15 16:19 |
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Second Decision |
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2021-12-14 03:39 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2021-12-23 05:42 |
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Articles in Press |
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2021-12-23 05:42 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-01-06 08:31 |
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Publish the Manuscript Online |
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2022-01-20 10:47 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Molecular mechanism of therapeutic approaches for human gastric cancer stem cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Hsi-Lung Hsieh, Li- Ching Cheng, Ming-Chin Yu, Ta-Sen Yeh and Ming-Ming Tsai |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Chang Gung Medical Research Foundation, Taoyuan, Taiwan |
CMRPF1I0031 |
| Chang Gung University of Science and Technology, Taoyuan, Taiwan |
ZRRPF3J0081-7 |
| Chang Gung University of Science and Technology, Taoyuan, Taiwan |
ZRRPF3K0111-6 |
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| Corresponding Author |
Ming-Ming Tsai, PhD, Associate Professor, Department of Nursing, Division of Basic Medical Sciences, Chang-Gung University of Science and Technology, No. 261 Wen-hwa 1 Road, Taoyuan 333, Taiwan. mmtsai@mail.cgust.edu.tw |
| Key Words |
Gastric cancer stem cells; Stem cell-surface markers; Tumor niche; Tumor microenvironment |
| Core Tip |
In recent years, cancer stem cells (CSCs) have become an extremely important subject in cancer biology. CSCs are considered to be a very small component of tumor tissues, which nevertheless have the capacity for self-renewal, differentiation, and epithelial–mesenchymal transition. CSCs can also explain the clinical phenomenon of resistance to chemotherapy or radiotherapy. Many studies have also found that CSCs are important for cancer initiation and metastasis and play a key role in cancer recurrence. Here, we review GCSC (gastric cancer stem cell)-targeting therapies in GC, including information on GCSC-surface/intracellular markers and GCSC-mediated pathways. This review also provides a brief description of the GCSC niche. Understanding the molecular mechanism of GCSC-targeting agents can help optimize the accuracy of diagnosis and prognosis and the selection of the most appropriate therapy for GC patients. |
| Publish Date |
2022-01-20 10:47 |
| Citation |
Hsieh HL, Cheng LC, Yu MC, Yeh TS, Tsai MM. Molecular mechanism of therapeutic approaches for human gastric cancer stem cells. World J Stem Cells 2022; 14(1): 76-91 |
| URL |
https://www.wjgnet.com/1948-0210/full/v14/i1/76.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v14.i1.76 |
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