Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	67140
Country	Italy

Received	2021-04-24 11:11
Peer-Review Started	2021-04-24 11:15
To Make the First Decision
Return for Revision	2021-06-14 07:24
Revised	2021-06-25 13:22
Second Decision	2021-12-02 03:26
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-12-03 06:56
Articles in Press	2021-12-03 06:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-12-08 10:45
Publish the Manuscript Online	2021-12-14 03:29

ISSN	1948-5190 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Efficacy and tolerability of high and low-volume bowel preparation compared: A real-life single-blinded large-population study
Manuscript Source	Invited Manuscript
All Author List	Vincenzo Occhipinti, Paola Soriani, Francesco Bagolini, Valentina Milani, Emanuele Rondonotti, Maria Laura Annunziata, Flaminia Cavallaro, Sara Vavassori, Maurizio Vecchi, Luca Pastorelli and Gian Eugenio Tontini
ORCID	Author(s) ORCID Number Vincenzo Occhipinti http://orcid.org/0000-0001-8623-7428 Paola Soriani http://orcid.org/0000-0001-8429-906X Francesco Bagolini http://orcid.org/0000-0003-4808-6096 Valentina Milani http://orcid.org/0000-0002-2989-981X Emanuele Rondonotti http://orcid.org/0000-0001-5013-0514 Maria Laura Annunziata http://orcid.org/0000-0002-1012-4117 Flaminia Cavallaro http://orcid.org/0000-0003-3103-1398 Sara Vavassori http://orcid.org/0000-0001-5912-1649 Maurizio Vecchi http://orcid.org/0000-0003-1558-8604 Luca Pastorelli http://orcid.org/0000-0002-2810-9951 Gian Eugenio Tontini http://orcid.org/0000-0002-8964-5686
Funding Agency and Grant Number
Corresponding Author	Luca Pastorelli, MD, PhD, Associate Professor, Gastroenterology Unit, IRCCS Policlinico San Donato, Piazza Malan, San Donato Milanese 20097, Italy. luca.pastorelli@unimi.it
Key Words	Bowel preparation volume; Polyethylene glycol; Bisacodyl; Colonoscopy; Colonic adenomas; Tolerability
Core Tip	Quality of bowel preparation is one of the main factors influencing outcomes of colonoscopy. This prospective real-life study compared bowel cleansing (according to the Boston Bowel Preparation Scale), clinically relevant colonoscopy outcomes (lesions detection rate) and tolerability of a standard high-volume bowel preparation and a low-volume preparation (2 L polyethylene glycol + bisacodyl). Even if the two study groups did not show differences in terms of adequate bowel preparation, the use of the high-volume preparation was associated with higher polyp and adenoma detection rates. There were no differences in terms of advanced adenomas, sessile/serrated lesions and cancer detections. Performance of low-volume preparation seems influenced by image resolution of colonoscopes, with fewer lesions detected compared to high-volume when using standard-definition colonoscopes. The two preparations were comparable in terms of patients’ self-reported tolerability, but complete adherence to preparation was more common with the low-volume product.
Publish Date	2021-12-14 03:29
Citation	Occhipinti V, Soriani P, Bagolini F, Milani V, Rondonotti E, Annunziata ML, Cavallaro F, Vavassori S, Vecchi M, Pastorelli L, Tontini GE. Efficacy and tolerability of high and low-volume bowel preparation compared: A real-life single-blinded large-population study. World J Gastrointest Endosc 2021; 13(12): 659-672
URL	https://www.wjgnet.com/1948-5190/full/v13/i12/659.htm
DOI	https://dx.doi.org/10.4253/wjge.v13.i12.659

Full Article (PDF)	WJGE-13-659.pdf
Full Article (Word)	WJGE-13-659.docx
Manuscript File	67140_Auto_Edited.docx
Answering Reviewers	67140-Answering reviewers.pdf
Audio Core Tip	67140-Audio core tip.aac
Biostatistics Review Certificate	67140-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	67140-Conflict-of-interest statement.pdf
Copyright License Agreement	67140-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	67140-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	67140-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	67140-Language certificate.pdf
Supplementary Material	67140-Supplementary material.pdf
Peer-review Report	67140-Peer-review(s).pdf
Scientific Editor Work List	67140-Scientific editor work list.pdf
CrossCheck Report	67140-CrossCheck report.pdf