Publication Name	World Journal of Gastroenterology
Manuscript ID	67204
Country	Italy

Received	2021-04-18 08:02
Peer-Review Started	2021-04-18 08:06
To Make the First Decision
Return for Revision	2021-06-03 17:45
Revised	2021-06-16 16:17
Second Decision	2022-01-11 03:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-01-11 19:36
Articles in Press	2022-01-11 19:36
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-01-13 09:17
Publish the Manuscript Online	2022-01-22 06:41

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Celiac disease: From genetics to epigenetics
Manuscript Source	Invited Manuscript
All Author List	Elisa Gnodi, Raffaella Meneveri and Donatella Barisani
ORCID	Author(s) ORCID Number Elisa Gnodi http://orcid.org/0000-0002-4390-6633 Raffaella Meneveri http://orcid.org/0000-0003-0791-5951 Donatella Barisani http://orcid.org/0000-0003-4592-6221
Funding Agency and Grant Number
Corresponding Author	Donatella Barisani, MD, MSc, Associate Professor, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, Monza 20900, Italy. donatella.barisani@unimib.it
Key Words	Celiac disease; Epigenetics; DNA methylation; Histone modifications; Long non-coding RNAs; MicroRNAs
Core Tip	Currently identified genes account only for half of celiac disease (CeD) predisposition. An important role could be played by epigenetics, inheritable traits without DNA sequence alterations, which could be influenced by gluten exposure. DNA methylation, histone modifications and non-coding RNAs act on different gene expression steps, from gene transcription to post-translational ones. Epigenetic changes can be additional predisposition factors or specific of CeD stages (active disease, gluten-free diet) as recently reported. Analysis of epigenetic data and their integration with transcriptome (by machine learning) can help to stratify patients, or discover new players in CeD pathogenesis, possible focus of novel therapeutic approaches.
Publish Date	2022-01-22 06:41
Citation	Gnodi E, Meneveri R, Barisani D. Celiac disease: From genetics to epigenetics. World J Gastroenterol 2022; 28(4): 449-463
URL	https://www.wjgnet.com/1007-9327/full/v28/i4/449.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i4.449

Full Article (PDF)	WJG-28-449.pdf
Full Article (Word)	WJG-28-449.docx
Manuscript File	67204_Auto_Edited.docx
Answering Reviewers	67204-Answering reviewers.pdf
Audio Core Tip	67204-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	67204-Conflict-of-interest statement.pdf
Copyright License Agreement	67204-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	67204-Language certificate.pdf
Peer-review Report	67204-Peer-review(s).pdf
Scientific Misconduct Check	67204-CrossCheck.png
Scientific Misconduct Check	67204-Bing-Gong ZM-2.png
Scientific Editor Work List	67204-Scientific editor work list.pdf
CrossCheck Report	67204-CrossCheck report.pdf