Publication Name	World Journal of Gastroenterology
Manuscript ID	6724
Country	Singapore

Received	2013-10-27 22:26
Peer-Review Started	2013-10-28 13:40
To Make the First Decision	2013-12-26 11:16
Return for Revision	2013-12-27 14:10
Revised	2014-01-11 11:00
Second Decision	2014-04-03 10:06
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-04-03 11:28
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-05-14 14:35
Publish the Manuscript Online	2014-05-28 11:45

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	miR-106b-25/miR-17-92 clusters: Polycistrons with oncogenic roles in hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Weiqi Tan, Yang Li, Seng-Gee Lim and Theresa MC Tan
Funding Agency and Grant Number
Corresponding Author	Dr. Theresa MC Tan, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, MD7, 8 Medical Drive, Singapore S117597, Singapore. bchtant@nus.edu.sgS117597, Singapore. bchtant@nus.edu.sg Tel: (65) 65163685 Fax: (65) 67791453
Key Words	miR-106b-25 cluster; miR-17-92 cluster; Hepatocellular carcinoma; Liver cirrhosis; MicroRNAs
Core Tip	The polycistronic miR-17-92 cluster has been characterized to play a role in tumorigenesis. Over-expression of the miR-17-92 cluster and its paralog, the miR-106b-25 cluster, has been reported in the development of cirrhosis and hepatocellular carcinoma. Various targets of these microRNAs have been identified, and these targets are involved in tumor growth, cell survival and metastasis. We describe the regulation of these clusters by c-Myc and E2F1, and discuss the roles of the various members of the clusters in affecting relevant target gene expression in the pathogenesis of hepatocellular carcinoma.
Publish Date	2014-05-28 11:45
Citation	Tan W, Li Y, Lim SG, Tan TMC. miR-106b-25/miR-17-92 clusters: Polycistrons with oncogenic roles in hepatocellular carcinoma. World J Gastroenterol 2014; 20(20): 5962-5972
URL	http://www.wjgnet.com/1007-9327/full/v20/i20/5962.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i20.5962

Full Article (PDF)	WJG-20-5962.pdf
Full Article (Word)	WJG-20-5962.doc
Manuscript File	6724-Review.docx
Answering Reviewers	6724-Answering reviewers.pdf
Copyright License Agreement	6724-Copyright assignment.pdf
Peer-review Report	6724-Peer review(s).pdf
Scientific Editor Work List	6724-Scientific editor work list.doc