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8/26/2014 5:16:00 PM | Browse: 423 | Download: 250
Publication Name World Journal of Gastroenterology
Manuscript ID 6724
Country/Territory Singapore
Received
2013-10-27 22:26
Peer-Review Started
2013-10-28 13:40
To Make the First Decision
2013-12-26 11:16
Return for Revision
2013-12-27 14:10
Revised
2014-01-11 11:00
Second Decision
2014-04-03 10:06
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-04-03 11:28
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-05-14 14:35
Publish the Manuscript Online
2014-05-28 11:45
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Topic Highlights
Article Title miR-106b-25/miR-17-92 clusters: Polycistrons with oncogenic roles in hepatocellular carcinoma
Manuscript Source Invited Manuscript
All Author List Weiqi Tan, Yang Li, Seng-Gee Lim and Theresa MC Tan
Funding Agency and Grant Number
Corresponding author Dr. Theresa MC Tan, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, MD7, 8 Medical Drive, Singapore S117597, Singapore. bchtant@nus.edu.sgS117597, Singapore. bchtant@nus.edu.sg Tel: (65) 65163685 Fax: (65) 67791453
Keywords miR-106b-25 cluster; miR-17-92 cluster; Hepatocellular carcinoma; Liver cirrhosis; MicroRNAs
Core Tip The polycistronic miR-17-92 cluster has been characterized to play a role in tumorigenesis. Over-expression of the miR-17-92 cluster and its paralog, the miR-106b-25 cluster, has been reported in the development of cirrhosis and hepatocellular carcinoma. Various targets of these microRNAs have been identified, and these targets are involved in tumor growth, cell survival and metastasis. We describe the regulation of these clusters by c-Myc and E2F1, and discuss the roles of the various members of the clusters in affecting relevant target gene expression in the pathogenesis of hepatocellular carcinoma.
Publish Date 2014-05-28 11:45
Citation Tan W, Li Y, Lim SG, Tan TMC. miR-106b-25/miR-17-92 clusters: Polycistrons with oncogenic roles in hepatocellular carcinoma. World J Gastroenterol 2014; 20(20): 5962-5972
Url http://www.wjgnet.com/1007-9327/full/v20/i20/5962.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i20.5962
Full Article (PDF) WJG-20-5962.pdf
Full Article (Word) WJG-20-5962.doc
Manuscript File 6724-Review.docx
Answering Reviewers 6724-Answering reviewers.pdf
Copyright License Agreement 6724-Copyright assignment.pdf
Peer-review Report 6724-Peer review(s).pdf
Scientific Editor Work List 6724-Scientific editor work list.doc