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Articles Published Processes
1/22/2022 6:41:14 AM | Browse: 504 | Download: 1087
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Received |
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2021-04-19 04:34 |
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Peer-Review Started |
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2021-04-19 04:37 |
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To Make the First Decision |
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Return for Revision |
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2021-06-23 03:23 |
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Revised |
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2021-06-29 03:15 |
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Second Decision |
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2022-01-10 05:44 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-01-10 22:08 |
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Articles in Press |
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2022-01-10 22:08 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-01-13 09:16 |
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Publish the Manuscript Online |
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2022-01-22 06:41 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Sarcopenia in hepatocellular carcinoma: Current knowledge and future directions
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Abhilash Perisetti, Hemant Goyal, Rachana Yendala, Saurabh Chandan, Benjamin Tharian and Ragesh Babu Thandassery |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Abhilash Perisetti, FACP, MBBS, MD, Academic Fellow, Department of Internal Medicine, Gastroenterology and Hepatology Division, University of Arkansas for Medical Sciences, 4301 W Markham St. , Little Rock, AR 72205, United States. abhilash.perisetti@gmail.com |
| Key Words |
Sarcopenia; Skeletal muscle; Hepatocellular carcinoma; Cirrhosis; Outcomes; Liver cancer |
| Core Tip |
Sarcopenia is a condition defined by the loss of skeletal muscle mass, quality and strength. It is commonly seen as a part of normal aging but can also be noted in multiple conditions such as chronic inflammation, cancers and use of drugs. Sarcopenia is common in liver cirrhosis and is associated with overall poor outcomes (disease-free survival). Recently, the adverse effects of sarcopenia in hepatocellular carcinoma (HCC) has been an area of intense interest. Altered bio-impedence and rapid muscle loss in liver diseases could alter skeletal muscle strength in these patients. Additionally, development of tumor-related cytokines can accelerate the sarcopenia progression which could provide insights into disease progression and response to various therapeutic options. While multiple scoring systems are available to evaluate the HCC progression, sarcopenia provides an additional functional status tool to further refine these systems. In this article, we summarize the role of sarcopenia in HCC progression and changes during locoregional and systemic treatments. |
| Publish Date |
2022-01-22 06:41 |
| Citation |
Perisetti A, Goyal H, Yendala R, Chandan S, Tharian B, Thandassery RB. Sarcopenia in hepatocellular carcinoma: Current knowledge and future directions. World J Gastroenterol 2022; 28(4): 432-448 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i4/432.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i4.432 |
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