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1/22/2022 6:41:14 AM | Browse: 368 | Download: 705
Publication Name World Journal of Gastroenterology
Manuscript ID 67241
Country/Territory United States
Received
2021-04-19 04:34
Peer-Review Started
2021-04-19 04:37
To Make the First Decision
Return for Revision
2021-06-23 03:23
Revised
2021-06-29 03:15
Second Decision
2022-01-10 05:44
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-01-10 22:08
Articles in Press
2022-01-10 22:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-01-13 09:16
Publish the Manuscript Online
2022-01-22 06:41
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title Sarcopenia in hepatocellular carcinoma: Current knowledge and future directions
Manuscript Source Invited Manuscript
All Author List Abhilash Perisetti, Hemant Goyal, Rachana Yendala, Saurabh Chandan, Benjamin Tharian and Ragesh Babu Thandassery
ORCID
Author(s) ORCID Number
Abhilash Perisetti http://orcid.org/0000-0003-4074-6395
Hemant Goyal http://orcid.org/0000-0002-9433-9042
Rachana Yendala http://orcid.org/0000-0002-5615-5525
Saurabh Chandan http://orcid.org/0000-0002-2661-6693
Benjamin Tharian http://orcid.org/0000-0002-7797-3738
Ragesh Babu Thandassery http://orcid.org/0000-0002-5357-4847
Funding Agency and Grant Number
Corresponding Author Abhilash Perisetti, FACP, MBBS, MD, Academic Fellow, Department of Internal Medicine, Gastroenterology and Hepatology Division, University of Arkansas for Medical Sciences, 4301 W Markham St. , Little Rock, AR 72205, United States. abhilash.perisetti@gmail.com
Key Words Sarcopenia; Skeletal muscle; Hepatocellular carcinoma; Cirrhosis; Outcomes; Liver cancer
Core Tip Sarcopenia is a condition defined by the loss of skeletal muscle mass, quality and strength. It is commonly seen as a part of normal aging but can also be noted in multiple conditions such as chronic inflammation, cancers and use of drugs. Sarcopenia is common in liver cirrhosis and is associated with overall poor outcomes (disease-free survival). Recently, the adverse effects of sarcopenia in hepatocellular carcinoma (HCC) has been an area of intense interest. Altered bio-impedence and rapid muscle loss in liver diseases could alter skeletal muscle strength in these patients. Additionally, development of tumor-related cytokines can accelerate the sarcopenia progression which could provide insights into disease progression and response to various therapeutic options. While multiple scoring systems are available to evaluate the HCC progression, sarcopenia provides an additional functional status tool to further refine these systems. In this article, we summarize the role of sarcopenia in HCC progression and changes during locoregional and systemic treatments.
Publish Date 2022-01-22 06:41
Citation Perisetti A, Goyal H, Yendala R, Chandan S, Tharian B, Thandassery RB. Sarcopenia in hepatocellular carcinoma: Current knowledge and future directions. World J Gastroenterol 2022; 28(4): 432-448
URL https://www.wjgnet.com/1007-9327/full/v28/i4/432.htm
DOI https://dx.doi.org/10.3748/wjg.v28.i4.432
Full Article (PDF) WJG-28-432.pdf
Full Article (Word) WJG-28-432.docx
Manuscript File 67241_Auto_Edited.docx
Answering Reviewers 67241-Answering reviewers.pdf
Audio Core Tip 67241-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 67241-Conflict-of-interest statement.pdf
Copyright License Agreement 67241-Copyright license agreement.pdf
Peer-review Report 67241-Peer-review(s).pdf
Scientific Misconduct Check 67241-CrossCheck.png
Scientific Editor Work List 67241-Scientific editor work list.pdf