| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Research & Experimental Medicine |
| Manuscript Type |
Basic Study |
| Article Title |
Liver injury changes the biological characters of serum small extracellular vesicles and reprograms hepatic macrophages in mice
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiu-Fang Lv, An-Qi Zhang, Wei-Qi Liu, Min Zhao, Jing Li, Li He, Li Cheng, Yu-Feng Sun, Gang Qin, Peng Lu, Yu-Hua Ji and Ju-Ling Ji |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81761128018 |
| National Natural Science Foundation of China |
81572871 |
| National Natural Science Foundation of China |
81272027 |
| Natural Science Foundation of Jiangsu Province |
BK20151277 |
| Science and Technology Project of Nantong City |
MS12020010 |
|
| Corresponding Author |
Ju-Ling Ji, MD, PhD, Director, Director, Professor, Department of Pathology, Medical School of Nantong University, No. 19 Qixiu Road, Nantong 226001, Jiangsu Province, China. jijuling@ntu.edu.cn |
| Key Words |
MicroRNA; Small RNA sequencing; Biomarker; Monocyte-derived macrophage; Resident macrophage |
| Core Tip |
The liver injury changed the concentration, morphology, and small RNA contents of serum small extracellular vesicles (sEVs). Altered serum sEV microRNAs (miRNAs) based on mouse studies were highly consistent with the circulating miRNAs reported in human liver diseases. Serum sEV miRNA signatures for acute liver injury (ALI) and chronic liver injury and a panel of miRNAs that can be used as a common marker for liver injury were established. ALI serum sEVs depolarized monocyte-derived macrophages and educated resident liver macrophages to transform into M2-like cells. Serum sEVs have good diagnostic and therapeutic potential for liver injury. |
| Publish Date |
2021-11-19 11:15 |
| Citation |
Lv XF, Zhang AQ, Liu WQ, Zhao M, Li J, He L, Cheng L, Sun YF, Qin G, Lu P, Ji YH, Ji JL. Liver injury changes the biological characters of serum small extracellular vesicles and reprograms hepatic macrophages in mice. World J Gastroenterol 2021; 27(43): 7509-7529 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i43/7509.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i43.7509 |
