Publication Name	World Journal of Gastroenterology
Manuscript ID	6729
Country	Spain

Received	2013-10-27 22:39
Peer-Review Started	2013-10-28 14:10
To Make the First Decision	2014-01-15 17:05
Return for Revision	2014-01-17 16:37
Revised
Second Decision	2014-05-29 20:18
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-05-29 20:49
Articles in Press	2014-05-29 21:03
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-06-11 16:38
Typeset the Manuscript	2014-10-15 19:00
Publish the Manuscript Online	2014-10-29 19:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Medicine, General & Internal
Manuscript Type	Topic Highlights
Article Title	Alcoholism: A systemic proinflammatory condition
Manuscript Source	Invited Manuscript
All Author List	Emilio González-Reimers, Francisco Santolaria-Fernández, María Candelaria Martín-González, Camino María Fernández-Rodríguez and Geraldine Quintero-Platt
Funding Agency and Grant Number
Corresponding Author	Emilio González-Reimers, MD, PhD, Professor, Servicio de Medicina Interna, Hospital Universitario de Canarias, Universidad de La Laguna, Ctra. Ofra, s/n, Tenerife, 38320 Canary Islands, Spain. egonrey@ull.es
Key Words	Alcoholism; Cytokines; Brain; Bone; Muscle; Oxidative damage; Atherosclerosis; Sepsis; Lung; Chronic pancreatitis; Alcoholic liver disease
Core Tip	Alcoholism is a multisystemic disease. In the last ten years it has been shown that an inflammatory response is triggered by ethanol itself, by reactive oxygen species derived from ethanol metabolism, and by increased amounts of mainly Gram-negative bacteria that reach liver and peripheral organs due to ethanol-induced increased intestinal permeability. In addition to direct organ injury caused by ethanol itself, these mechanisms especially affect end organs such as brain, lung, muscle, bone, heart, blood vessels, pancreas, and the immune system. The main features of these effects are highlighted in this review.
Publish Date	2014-10-29 19:34
Citation	González-Reimers E, Santolaria-Fernández F, Martín-González MC, Fernández-Rodríguez CM, Quintero-Platt G. Alcoholism: A systemic proinflammatory condition. World J Gastroenterol 2014; 20(40): 14660-14671
URL	http://www.wjgnet.com/1007-9327/full/v20/i40/14660.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i40.14660

Full Article (PDF)	WJG-20-14660.pdf
Full Article (Word)	WJG-20-14660.doc
Manuscript File	6729-Review.doc
Answering Reviewers	6729-Answering reviewers.pdf
Copyright License Agreement	6729-Copyright assignment.pdf
Peer-review Report	6729-Peer review(s).pdf
Scientific Misconduct Check	6729-CrossCheck.jpg
Scientific Editor Work List	6729-Scientific editor work list.pdf