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Articles Published Processes
11/12/2021 11:22:24 AM | Browse: 561 | Download: 812
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Received |
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2021-04-29 14:56 |
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Peer-Review Started |
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2021-04-29 14:59 |
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To Make the First Decision |
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Return for Revision |
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2021-06-16 01:43 |
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Revised |
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2021-06-28 04:13 |
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Second Decision |
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2021-08-18 03:20 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-08-18 08:58 |
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Articles in Press |
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2021-08-18 08:58 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-09-08 02:14 |
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Typeset the Manuscript |
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2021-11-09 09:27 |
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Publish the Manuscript Online |
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2021-11-12 11:22 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Regulatory role of the transforming growth factor-β signaling pathway in the drug resistance of gastrointestinal cancers
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Xiaoqun Lv and Guoxiong Xu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Fourth Training Programme for the Outstanding Young Talents, Jinshan Health Commission, China |
JSYQ201904 |
| Key Construction Project on Clinical Pharmacy of Shanghai, China |
2019-1229 |
| National Natural Science Foundation of China |
81872121 |
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| Corresponding Author |
Guoxiong Xu, MD, PhD, Academic Fellow, Director, Director, Full Professor, Senior Scientist, Research Center for Clinical Medicine, Jinshan Hospital, Fudan University, No. 1508 Longhang Road, Jinshan District, Shanghai 201508, China. guoxiong.xu@fudan.edu.cn |
| Key Words |
Drug resistance; Gastrointestinal cancer; Transforming growth factor-β; Epithelial-mesenchymal transition; Cancer stem cells; MicroRNAs |
| Core Tip |
The transforming growth factor-β (TGF-β) signaling pathway is involved in the drug resistance of gastrointestinal (GI) cancers. This review summarizes the current understanding of the roles played by the TGF-β signaling pathway in resistance to conventional chemotherapy, targeted therapy, immunotherapy, and traditional medicine in GI cancers as well as the various processes by which this occurs, including epithelial-mesenchymal transition, cancer stem cell development, tumor microenvironment alteration, and microRNA biogenesis. |
| Publish Date |
2021-11-12 11:22 |
| Citation |
Lv X, Xu G. Regulatory role of the transforming growth factor-β signaling pathway in the drug resistance of gastrointestinal cancers. World J Gastrointest Oncol 2021; 13(11): 1648-1667 |
| URL |
https://www.wjgnet.com/1948-5204/full/v13/i11/1648.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v13.i11.1648 |
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