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Articles Published Processes
11/12/2021 11:22:24 AM | Browse: 397 | Download: 442
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Received |
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2021-04-29 14:56 |
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Peer-Review Started |
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2021-04-29 14:59 |
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To Make the First Decision |
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Return for Revision |
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2021-06-16 01:43 |
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Revised |
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2021-06-28 04:13 |
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Second Decision |
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2021-08-18 03:20 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2021-08-18 08:58 |
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Articles in Press |
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2021-08-18 08:58 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-09-08 02:14 |
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Typeset the Manuscript |
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2021-11-09 09:27 |
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Publish the Manuscript Online |
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2021-11-12 11:22 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Regulatory role of the transforming growth factor-β signaling pathway in the drug resistance of gastrointestinal cancers
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Xiaoqun Lv and Guoxiong Xu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Fourth Training Programme for the Outstanding Young Talents, Jinshan Health Commission, China |
JSYQ201904 |
| Key Construction Project on Clinical Pharmacy of Shanghai, China |
2019-1229 |
| National Natural Science Foundation of China |
81872121 |
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| Corresponding Author |
Guoxiong Xu, MD, PhD, Academic Fellow, Director, Full Professor, Senior Scientist, Research Center for Clinical Medicine, Jinshan Hospital, Fudan University, No. 1508 Longhang Road, Jinshan District, Shanghai 201508, China. guoxiong.xu@fudan.edu.cn |
| Key Words |
Drug resistance; Gastrointestinal cancer; Transforming growth factor-β; Epithelial-mesenchymal transition; Cancer stem cells; MicroRNAs |
| Core Tip |
The transforming growth factor-β (TGF-β) signaling pathway is involved in the drug resistance of gastrointestinal (GI) cancers. This review summarizes the current understanding of the roles played by the TGF-β signaling pathway in resistance to conventional chemotherapy, targeted therapy, immunotherapy, and traditional medicine in GI cancers as well as the various processes by which this occurs, including epithelial-mesenchymal transition, cancer stem cell development, tumor microenvironment alteration, and microRNA biogenesis. |
| Publish Date |
2021-11-12 11:22 |
| Citation |
Lv X, Xu G. Regulatory role of the transforming growth factor-β signaling pathway in the drug resistance of gastrointestinal cancers. World J Gastrointest Oncol 2021; 13(11): 1648-1667 |
| URL |
https://www.wjgnet.com/1948-5204/full/v13/i11/1648.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v13.i11.1648 |
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