| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Recombinant angiopoietin-like protein 4 attenuates intestinal barrier structure and function injury after ischemia/reperfusion
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zi-Yi Wang, Jian-Yu Lin, Yang-Rong Feng, De-Shun Liu, Xu-Zi Zhao, Tong Li, Si-Yuan Li, Jing-Chao Sun, Shu-Feng Li, Wen-Yan Jia and Hui-Rong Jing |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81600446 |
| Science and Technology of Traditional Chinese Medicine Foundation in Qingdao |
2021-zyyz03 |
| Science and technology development of Medicine and health Foundation in Shandong Province, China |
202004010508 |
|
| Corresponding Author |
Hui-Rong Jing, MD, PhD, Associate Professor, Surgeon, Department of General Surgery, Qingdao Municipal Hospital, Qingdao University, No. 5 Donghai Middle Road, Southern District, Qingdao 266071, Shandong Province, China. jhrdlmu_edu@126.com |
| Key Words |
Intestinal barrier breakdown; Myosin light chain kinase; COVID-19; Intestinal ischemia/reperfusion; Angiopoietin-like protein 4 |
| Core Tip |
To push the improvement of therapy on intestinal barrier dysfunction induced by ischemia/reperfusion (I/R) is still be challenging. Almost recently, studies indicated patients who suffered coronavirus disease-2019 associated with intestinal hypoperfusion. We investigated the effect of Recombinant human angiopoietin-like protein 4 (rhANGPTL4) on intestinal barrier structure and function deterioration using intestinal I/R models in rats as well as hypoxia/reoxygenation models in cells. Intestinal barrier indicators, associated with inflammatory and oxidative cascade, excessive activation of cellular autophagy and apoptosis were compared. Our results indicated rhANGPTL4 behaved as a promising therapeutic agent for intestinal I/R-induced intestine injury. |
| Publish Date |
2021-08-25 02:11 |
| Citation |
Wang ZY, Lin JY, Feng YR, Liu DS, Zhao XZ, Li T, Li SY, Sun JC, Li SF, Jia WY, Jing HR. Recombinant angiopoietin-like protein 4 attenuates intestinal barrier structure and function injury after ischemia/reperfusion. World J Gastroenterol 2021; 27(32): 5404-5423 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i32/5404.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i32.5404 |
