| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Basic Study |
| Article Title |
CPEB1, a novel risk gene in recent-onset schizophrenia, contributes to mitochondrial complex I defect caused by a defective provirus ERVWE1
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Ya-Ru Xia, Xiao-Cui Wei, Wen-Shi Li, Qiu-Jin Yan, Xiu-Lin Wu, Wei Yao, Xu-Hang Li and Fan Zhu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81971943 |
| National Natural Science Foundation of China |
81772196 |
| National Natural Science Foundation of China |
31470264 |
| National Natural Science Foundation of China |
81271820 |
| National Natural Science Foundation of China |
30870789 |
| National Natural Science Foundation of China |
30300117 |
| Stanley Foundation of United States |
06R-1366 |
| Medical Science Advancement Program (Basic Medical Sciences) of Wuhan University |
TFJC 2018002 |
|
| Corresponding Author |
Fan Zhu, PhD, Director, Director, Doctor, Doctor, Professor, State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy & Immunology, Department of Medical Microbiology, School of Medicine, Wuhan University, No. 185 Donghu Road, Wuhan 430071, Hubei Province, China. fanzhu@whu.edu.cn |
| Key Words |
ERVWE1; CPEB1; NADH dehydrogenase ubiquinone flavoprotein 2; complex I; Pseudogene |
| Core Tip |
Schizophrenia is a devastating psychiatric disorder. Clinical studies suggest complex I deficits and abnormal expression of ERVWE1 in schizophrenia. Here, we found that CPEB1 might be a novel blood-based biomarker for schizophrenia. Further analysis indicated ERVWE1 negatively correlated with CPEB1 and NADH dehydrogenase ubiquinone flavoprotein 2 (NDUFV2) in schizophrenia patients. Further studies implied that CPEB1 functioned as a mediator of the NDUFV2 pseudogene (NDUFV2P1)/NDUFV2 pathway induced by ERVWE1. Moreover, ERVWE1 inhibited complex I activity via CPEB1/NDUFV2P1/NDUFV2 pathway in schizophrenia. These results identified CPEB1 and NDUFV2 as two independent risk factors for schizophrenia. Our findings also exhibited the role of ERVWE1 in modulating mitochondrial energy metabolism in schizophrenia. |
| Publish Date |
2021-11-17 02:18 |
| Citation |
Xia YR, Wei XC, Li WS, Yan QJ, Wu XL, Yao W, Li XH, Zhu F. CPEB1, a novel risk gene in Recent-Onset schizophrenia, contributes to mitochondrial complex I defect caused by a defective provirus ERVWE1. World J Psychiatr 2021; 11(11): 1075-1094 |
| URL |
https://www.wjgnet.com/2220-3206/full/v11/i11/1075.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v11.i11.1075 |
