Publication Name	World Journal of Gastroenterology
Manuscript ID	6742
Country	China

Received	2013-10-28 11:26
Peer-Review Started	2013-10-29 10:38
To Make the First Decision	2013-12-04 09:22
Return for Revision	2013-12-05 11:52
Revised	2013-12-17 14:19
Second Decision	2014-03-05 14:13
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-03-05 15:23
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-03-25 10:49
Typeset the Manuscript	2014-04-28 10:09
Publish the Manuscript Online	2014-05-18 12:31

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Infectious Diseases
Manuscript Type	Topic Highlights
Article Title	Optimization therapy for the treatment of chronic hepatitis B
Manuscript Source	Invited Manuscript
All Author List	En-Qiang Chen and Hong Tang
Funding Agency and Grant Number	Funding Agency Grant Number National Twelve-Five Project of China 2012ZX10002007-001-003 National Twelve-Five Project of China 2013ZX10002001
Corresponding Author	Hong Tang, Professor, Center of Infectious Diseases, West China Hospital of Sichuan University, No. 37 Guo Xue Xiang, Wuhou District, Chengdu 610041, Sichuan Province, China. htang6198@hotmail.com
Key Words	Chronic hepatitis B; Nucleos(t)ide analog; Interferon; Suboptimal response; Optimization therapy
Core Tip	Optimization therapy is a personalized strategy, and it aims to achieve profound and sustained inhibition of hepatitis B virus replication, and to reduce the likelihood of subsequent disease progression. The key points of optimization therapy are to initiate antiviral therapy with an appropriate agent at the correct time point based on baseline characteristics, and to timely adjust the treatment by dynamic monitoring of the on-treatment response. However, the current understanding of optimization therapy is still very limited, and many issues still need further research.
Publish Date	2014-05-18 12:31
Citation	Chen EQ, Tang H. Optimization therapy for the treatment of chronic hepatitis B. World J Gastroenterol 2014; 20(19): 5730-5736
URL	http://www.wjgnet.com/1007-9327/full/v20/i19/5730.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i19.5730

Full Article (PDF)	WJG-20-5730.pdf
Full Article (Word)	WJG-20-5730.doc
Manuscript File	6742-Review.doc
Answering Reviewers	6742-Answering reviewers.pdf
Copyright License Agreement	6742-Copyright assignment.pdf
Peer-review Report	6742-Peer review(s).pdf
Scientific Editor Work List	6742-Scientific editor work list.doc