| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Detailing the ultrastructure’s increase of prion protein in pancreatic adenocarcinoma
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Matteo Bianchini, Maria Anita Giambelluca, Maria Concetta Scavuzzo, Gregorio Di Franco, Simone Guadagni, Matteo Palmeri, Niccolò Furbetta, Desirée Gianardi, Niccola Funel, Claudio Ricci, Raffaele Gaeta, Luca Emanuele Pollina, Alfredo Falcone, Caterina Vivaldi, Giulio Di Candio, Francesca Biagioni, Carla Letizia Busceti, Luca Morelli and Francesco Fornai |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Tizzi Foundation |
|
| Arpa Foundation (www.fondazionearpa.it) |
|
|
| Corresponding Author |
Luca Morelli, MD, Professor, General Surgery Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Paradisa 2, Pisa 56124, Italy. luca.morelli@unipi.it |
| Key Words |
Pancreatic ductal adenocarcinoma; Prion protein; Western blotting; Electron microscopy; Cellular compartmentalization; Neuroinvasion |
| Core Tip |
Pancreatic ductal adenocarcinoma (PDAC) is an extremely lethal cancer and we are far away from understanding its biology. Recent in vitro evidence hypothesizes some role of cellular prion protein (PrPc) in PDAC carcinogenesis. We found that this protein is over-expressed in vivo within PDAC tissue of surgically resected patients, here we quantify the stoichiometric increase and provide evidence for a shift towards a nuclear compartmentalization. Such a protein amount is associated with poorer post-surgical prognosis and neuro-invasion. Thus, PrPc might be a key in the puzzled evidence of PDAC biology leading to better comprehend and cure such an aggressive disorder. |
| Publish Date |
2021-11-10 07:13 |
| Citation |
Bianchini M, Giambelluca MA, Scavuzzo MC, Di Franco G, Guadagni S, Palmeri M, Furbetta N, Gianardi D, Funel N, Ricci C, Gaeta R, Pollina LE, Falcone A, Vivaldi C, Di Candio G, Biagioni F, Busceti CL, Morelli L, Fornai F. Detailing the ultrastructure’s increase of prion protein in pancreatic adenocarcinoma. World J Gastroenterol 2021; 27(42): 7324-7339 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i42/7324.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i42.7324 |
