Publication Name	World Journal of Clinical Cases
Manuscript ID	67467
Country	China

Received	2021-04-26 07:55
Peer-Review Started	2021-04-26 07:59
To Make the First Decision
Return for Revision	2021-10-18 00:23
Revised	2021-10-29 11:03
Second Decision	2021-11-22 03:29
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-11-28 07:37
Articles in Press	2021-11-28 07:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-12-14 09:24
Publish the Manuscript Online	2021-12-30 08:21

ISSN	2307-8960 (online)
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Category	Dermatology
Manuscript Type	Clinical Trials Study
Article Title	Low-dose intralesional injection of 5-fluorouracil and triamcinolone reduces tissue resident memory T cells in chronic eczema
Manuscript Source	Unsolicited Manuscript
All Author List	Yun Wu, Guo-Jiang Wang, Hui-Qiong He, Hai-Hong Qin, Wen-Tong Shen, Yue Yu, Xun Zhang, Mao-Lin Zhou and Jian-Biao Fei
ORCID	Author(s) ORCID Number Yun Wu http://orcid.org/0000-0002-2419-5813 Guo-Jiang Wang http://orcid.org/0000-0002-7101-3226 Hui-Qiong He http://orcid.org/0000-0002-1783-4429 Hai-Hong Qin http://orcid.org/0000-0002-9853-5737 Wen-Tong Shen http://orcid.org/0000-0003-1042-0706 Yue Yu http://orcid.org/0000-0002-0213-4534 Xun Zhang http://orcid.org/0000-0001-8454-4643 Mao-Lin Zhou http://orcid.org/0000-0001-8159-8136 Jian-Biao Fei http://orcid.org/0000-0002-9427-8657
Funding Agency and Grant Number	Funding Agency Grant Number Pudong New District Science and Technology Development Fund People’s Livelihood Scientific Research Special Fund PKJ2018-Y42 Shanghai Pudong New District Health System Discipline Construction Project PWZzk 2017-14 School-level Scientific Research Project of Shanghai University of Medicine and Health Sciences Affiliated with Zhoupu Hospital ZPXM-2019A-13
Corresponding Author	Jian-Biao Fei, MD, Attending Doctor, Department of Dermatology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, No. 1500 Zhouyuan Road, Pudong District, Shanghai 201318, China. zpyyfeijianbiao@163.com
Key Words	Chronic eczema; 5-Fluorouracil; Triamcinolone; Intralesional injection; Tissue resident memory T cell
Core Tip	Chronic eczema is characterized by recurrent itchy papules and plaques with lichenification and hyperpigmentation, in which tissue resident memory T (TRM) cells play a significant role. Intralesional injection of 5-fluorouracil (5-FU) and triamcinolone (TA) can effectively reduce local inflammation and recurrence in a mouse model, but no clinical study has been reported. In this study, low-dose intralesional injection of 5-FU+TA was found to effectively and safely treat the localized rash, by significantly reducing the retention of TRM cells in the skin lesion, and to lower the relapse rate of chronic eczema. This combination may provide a new treatment option for chronic eczema patients with hypertrophy and localized rash.
Publish Date	2021-12-30 08:21
Citation	Wu Y, Wang GJ, He HQ, Qin HH, Shen WT, Yu Y, Zhang X, Zhou ML, Fei JB. Low-dose intralesional injection of 5-fluorouracil and triamcinolone reduces tissue resident memory T cells in chronic eczema. World J Clin Cases 2022; 10(1): 166-176
URL	https://www.wjgnet.com/2307-8960/full/v10/i1/166.htm
DOI	https://dx.doi.org/10.12998/wjcc.v10.i1.166

Full Article (PDF)	WJCC-10-166.pdf
Full Article (Word)	WJCC-10-166.docx
Manuscript File	67467_Auto_Edited.docx
Answering Reviewers	67467-Answering reviewers.pdf
Audio Core Tip	67467-Audio core tip.m4a
Biostatistics Review Certificate	67467-Biostatistics statement.pdf
Clinical Trial Registration Statement	67467-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	67467-Conflict-of-interest statement.pdf
Copyright License Agreement	67467-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	67467-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	67467-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	67467-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	67467-Language certificate.pdf
Peer-review Report	67467-Peer-review(s).pdf
Scientific Misconduct Check	67467-CrossCheck.png
Scientific Editor Work List	67467-Scientific editor work list.pdf
CrossCheck Report	67467-CrossCheck report.pdf