Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	67470
Country	India

Received	2021-04-25 09:59
Peer-Review Started	2021-04-25 10:03
To Make the First Decision
Return for Revision	2021-06-17 05:29
Revised	2021-07-05 04:55
Second Decision	2022-02-25 06:33
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-02-27 23:39
Articles in Press	2022-02-27 23:39
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-12-13 23:00
Typeset the Manuscript	2022-03-03 01:33
Publish the Manuscript Online	2022-03-09 12:30

ISSN	2219-2808 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Anesthesiology
Manuscript Type	Opinion Review
Article Title	Current status of nitrous oxide use in pediatric patients
Manuscript Source	Invited Manuscript
All Author List	Nishkarsh Gupta, Anju Gupta and Vishnu Narayanan M R
ORCID	Author(s) ORCID Number Nishkarsh Gupta http://orcid.org/0000-0002-8444-2564 Anju Gupta http://orcid.org/0000-0003-1726-1488 Vishnu Narayanan M R http://orcid.org/0000-0002-6538-5357
Funding Agency and Grant Number
Corresponding Author	Anju Gupta, MD, Assistant Professor, Department of Anesthesiology, Pain Medicine and Critical Care, AIIMS, Room No. 6, Porta Cabin, Fourth floor teaching block, New Delhi 110029, Delhi, India. dranjugupta2009@rediffmail.com
Key Words	Child; Nitrous oxide; Vitamin B12; Vulnerable populations; Anesthesiology; Anesthetics; Folic acid; Metabolic networks and pathways
Core Tip	The literature is insufficient presently to advise either the routine use or complete elimination of nitrous oxide, and further research is needed to fully establish its role in pediatric anesthesia practice. No major adverse effects have been reported in large trials on the use of nitrous oxide in children despite the prevailing concerns over its safety in this population. A reasonable and balanced approach should be adopted to individualize its use considering its risks and benefits as related to a particular case.
Publish Date	2022-03-09 12:30
Citation	Gupta N, Gupta A, Narayanan V. Current status of nitrous oxide use in pediatric patients. World J Clin Pediatr 2021; 11(2): 93-104
URL	https://www.wjgnet.com/2219-2808/full/v11/i2/93.htm
DOI	https://dx.doi.org/10.5409/wjcp.v11.i2.93

Full Article (PDF)	WJCP-11-93.pdf
Full Article (Word)	WJCP-11-93.docx
Manuscript File	67470_Auto_Edited-YXJW-FilipodiaCL.docx
Answering Reviewers	67470-Answering reviewers.pdf
Audio Core Tip	67470-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	67470-Conflict-of-interest_statement.pdf
Copyright License Agreement	67470-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	67470-Language certificate.pdf
Peer-review Report	67470-Peer-review(s).pdf
Scientific Misconduct Check	67470-BIng-Liu M-1.png
Scientific Misconduct Check	67470-BIng-Wu YXJ-2.png
Scientific Editor Work List	67470-Scientific editor work list.pdf
CrossCheck Report	67470-CrossCheck report.pdf