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Articles Published Processes
12/3/2021 7:34:23 AM | Browse: 617 | Download: 1993
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Received |
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2021-04-28 01:12 |
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Peer-Review Started |
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2021-04-28 01:14 |
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To Make the First Decision |
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Return for Revision |
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2021-06-13 02:03 |
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Revised |
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2021-07-06 15:00 |
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Second Decision |
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2021-11-19 03:15 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-11-21 19:55 |
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Articles in Press |
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2021-11-21 19:55 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-11-24 23:35 |
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Publish the Manuscript Online |
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2021-12-03 07:34 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Clinical and Translational Research |
| Article Title |
MicroRNAs expression influence in ulcerative colitis and Crohn's disease: A pilot study for the identification of diagnostic biomarkers
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ana Elisa Valencise Quaglio, Felipe Jose Santaella, Maria Aparecida Marchesan Rodrigues, Ligia Yukie Sassaki and Luiz Claudio Di Stasi |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| São Paulo Research Foundation (FAPESP) |
2017/03959-8 |
| São Paulo Research Foundation (FAPESP) |
2015/15267-8 |
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| Corresponding Author |
Ana Elisa Valencise Quaglio, PhD, Professor, Research Scientist, Laboratory of Phytomedicines, Pharmacology and Biotechnology (PhytoPharmaTec), Department of Biophysics and Pharmacology, São Paulo State University (Unesp), Institute of Biosciences, R. Prof. Dr. Antônio Celso Wagner Zanin, 250 - Distrito de Rubião Junior, Botucatu 18618-689, São Paulo, Brazil. anaequaglio@hotmail.com |
| Key Words |
Crohn’s disease; Ulcerative colitis; Inflammatory bowel disease; miRNA; Differential diagnosis; Biomarker |
| Core Tip |
This study identified 27 microRNAs (miRNAs) with significantly different expression levels between Crohn’s disease (CD) and ulcerative colitis (UC) patients. Five miRNAs whose expression levels were significantly lower in the UC patients than in the CD patients were selected for enrichment analysis, which revealed enrichment in certain signaling pathways that were mostly associated with cancer-related processes. The characterization and comparison of the differentially expressed miRNAs in this study could lead to novel diagnostic biomarkers to differentiate UC from CD. These markers might also predict prognosis, help elucidate the distinct pathophysiology of each disease, and lead to novel therapeutic target identification. |
| Publish Date |
2021-12-03 07:34 |
| Citation |
Quaglio AEV, Santaella FJ, Rodrigues MAM, Sassaki LY, Di Stasi LC. MicroRNAs expression influence in ulcerative colitis and Crohn's disease: A pilot study for the identification of diagnostic biomarkers. World J Gastroenterol 2021; 27(45): 7801-7812 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i45/7801.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i45.7801 |
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