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Articles Published Processes
12/3/2021 7:34:23 AM | Browse: 532 | Download: 1299
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Received |
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2021-04-27 08:05 |
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Peer-Review Started |
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2021-04-27 08:07 |
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To Make the First Decision |
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Return for Revision |
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2021-06-13 03:55 |
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Revised |
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2021-06-25 15:25 |
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Second Decision |
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2021-11-19 03:15 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-11-21 19:56 |
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Articles in Press |
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2021-11-21 19:56 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-11-24 23:35 |
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Publish the Manuscript Online |
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2021-12-03 07:34 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Frontier |
| Article Title |
Chronic rejection after liver transplantation: Opening the Pandora’s box
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Roberta Angelico, Bruno Sensi, Tommaso M Manzia, Giuseppe Tisone, Giuseppe Grassi, Alessandro Signorello, Martina Milana, Ilaria Lenci and Leonardo Baiocchi |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Leonardo Baiocchi, MD, PhD, Associate Professor, Hepatology Unit, University of Tor Vergata, Viale Oxford 81, Rome 00100, Italy. baiocchi@uniroma2.it |
| Key Words |
Liver transplantation; Chronic rejection; Immunosuppression; T cell-mediated rejection; Antibody-mediated rejection; Donor-specific antibody; Re-transplantation; Graft loss; Complications; Outcomes |
| Core Tip |
Chronic rejection (CR) still represents a cause of graft loss after liver transplantation. Recent advances in understanding the pathways leading to CR, through a T cell-mediated or antibody mediated injury, are opening new strategies for its management. Early detection of CR, tailored immunosuppressive regimen and strict monitoring are essential to prevent graft loss rejection-related requiring re-transplantation. The current perspectives aim to identify non-invasive biomarkers predicting patients at risk for CR in order to prevent irreversible liver damage by adequate immunosuppressive regimen and improving long-term outcomes after liver transplantation. |
| Publish Date |
2021-12-03 07:34 |
| Citation |
Angelico R, Sensi B, Manzia TM, Tisone G, Grassi G, Signorello A, Milana M, Lenci I, Baiocchi L. Chronic rejection after liver transplantation: Opening the Pandora’s box. World J Gastroenterol 2021; 27(45): 7771-7783 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i45/7771.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i45.7771 |
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