Publication Name	World Journal of Gastroenterology
Manuscript ID	6759
Country	United States

Received	2013-10-28 14:12
Peer-Review Started	2013-10-29 12:05
To Make the First Decision	2013-12-04 08:53
Return for Revision	2013-12-04 19:26
Revised	2013-12-15 00:12
Second Decision	2014-01-15 20:15
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-01-15 20:29
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-02-24 14:20
Publish the Manuscript Online	2014-03-06 14:13

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Topic Highlights
Article Title	Embryonic stem cell factors and pancreatic cancer
Manuscript Source	Invited Manuscript
All Author List	Marta Herreros-Villanueva, Luis Bujanda, Daniel D Billadeau and Jin-San Zhang
Funding Agency and Grant Number	Funding Agency Grant Number Universidad del Pais Vasco, Instituto Biodonostia, San Sebastian CIBERehd (red de enfermedades hepaticas y digestivas) American Cancer Society institutional award Mayo Clinic Pancreatic Cancer SPORE CA102701
Corresponding Author	Jin-San Zhang, MD, PhD, Division of Oncology Research, Schulze Center for Novel Therapeutics, Mayo Clinic College of Medicine, Rochester, MN 55905, United States. zhang.jinsan@mayo.edu
Key Words	Embryonic stem cells; NANOG; SOX2; OCT4; Pluripotency; Pancreatic cancer; Cancer stem cells
Core Tip	Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human cancer due to its early metastasis and lack of response to chemoradiotherapy. Pancreatic cancer stem cells (CSCs) are implicated in tumorigenesis and metastasis as well as therapy resistance, therefore represent a potential target for effective therapeutic options. Recent publications including our own research demonstrate that key embryonic stem cell (ESC) factors, such as OCT4, NANOG and SOX2, are abbrently expressed in PDAC and contribute to pancreatic CSC-like characteristics, such as self-renewal and de-differentiation. This review aims to summarize our current knowledge on the role of ESC factors particulary SOX2 in regulating pancreatic CSC-like feature and implication for therapy.
Publish Date	2014-03-06 14:13
Citation	Herreros-Villanueva M, Bujanda L, Billadeau DD, Zhang JS. Embryonic stem cell factors and pancreatic cancer. World J Gastroenterol 2014; 20(9): 2247-2254
URL	http://www.wjgnet.com/1007-9327/full/v20/i9/2247.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i9.2247

Full Article (PDF)	WJG-20-2247.pdf
Full Article (Word)	WJG-20-2247.doc
Manuscript File	6759-Review.docx
Answering Reviewers	6759-Answering reviewers.pdf
Copyright License Agreement	6759-Copyright assignment.pdf
Peer-review Report	6759-Peer review(s).pdf
Scientific Editor Work List	6759-Scientific editor work list.doc