Publication Name	World Journal of Gastroenterology
Manuscript ID	67639
Country	Japan

Received	2021-05-19 19:37
Peer-Review Started	2021-05-19 19:40
To Make the First Decision
Return for Revision	2021-06-12 02:56
Revised	2021-07-17 16:26
Second Decision	2022-04-02 02:09
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-04-04 06:01
Articles in Press	2022-04-04 06:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-04-18 02:48
Publish the Manuscript Online	2022-05-17 12:57

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Transplantation
Manuscript Type	Basic Study
Article Title	Ultrastructural changes in porcine liver sinusoidal endothelial cells of machine perfused liver donated after cardiac death
Manuscript Source	Invited Manuscript
All Author List	Hiroki Bochimoto, Yo Ishihara, Nur Khatijah Mohd Zin, Hiroyoshi Iwata, Daisuke Kondoh, Hiromichi Obara and Naoto Matsuno
ORCID	Author(s) ORCID Number Hiroki Bochimoto http://orcid.org/0000-0002-1708-0348 Yo Ishihara http://orcid.org/0000-0002-5675-4026 Nur Khatijah Mohd Zin http://orcid.org/0000-0002-5584-3019 Hiroyoshi Iwata http://orcid.org/0000-0002-3970-0827 Daisuke Kondoh http://orcid.org/0000-0002-3015-5156 Hiromichi Obara http://orcid.org/0000-0003-0662-6138 Naoto Matsuno http://orcid.org/0000-0001-5186-7331
Funding Agency and Grant Number
Corresponding Author	Hiroki Bochimoto, MD, PhD, Assistant Professor, Department of Cell Physiology, The Jikei University School of Medicine, 3-25-8 Nishishimbashi, Minato-ku 105-8461, Tokyo, Japan. botimoto@jikei.ac.jp
Key Words	Liver; Sinusoidal endothelial cells; Warm ischemia; Machine perfusion preservation; Transplantation; Ultrastructure
Core Tip	The importance of understanding liver sinusoidal endothelial cells (LSEC) damage in regulating liver injury during machine perfusion (MP) preservation has been emphasized. Here, we comparatively analyzed the ultrastructural changes in the LSEC and sinusoids around them at four hours after hypothermic MP (HMP) or midthermic MP (MMP). MP alleviated the ER damage of LSEC caused by warm ischemia. Moreover, MMP temperature conditions restore the metabolism of LSEC via the normalization of cristae of mitochondria and prevent the damage of the liver graft by share stress.
Publish Date	2022-05-17 12:57
Citation	Bochimoto H, Ishihara Y, Mohd Zin NK, Iwata H, Kondoh D, Obara H, Matsuno N. Ultrastructural changes in porcine liver sinusoidal endothelial cells of machine perfused liver donated after cardiac death. World J Gastroenterol 2022; 28(19): 2100-2111
URL	https://www.wjgnet.com/1007-9327/full/v28/i19/2100.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i19.2100

Full Article (PDF)	WJG-28-2100.pdf
Full Article (Word)	WJG-28-2100.docx
The ARRIVE Guidelines	67639-The-ARRIVE-Guidelines-revision.pdf
Manuscript File	67639_Auto_Edited.docx
Answering Reviewers	67639-Answering reviewers.pdf
Audio Core Tip	67639-Audio core tip.mp3
Biostatistics Review Certificate	67639-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	67639-Conflict-of-interest statement.pdf
Copyright License Agreement	67639-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	67639-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	67639-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	67639-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	67639-Language certificate.pdf
Supplementary Material	67639-Supplementary material.pdf
Peer-review Report	67639-Peer-review(s).pdf
Scientific Misconduct Check	67639-Bing-Gao CC-1.jpg
Scientific Misconduct Check	67639-Bing-Chang KL-2.jpg
Scientific Editor Work List	67639-Scientific editor work list.pdf
CrossCheck Report	67639-CrossCheck report.pdf