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Articles Published Processes
10/22/2021 1:53:28 PM | Browse: 340 | Download: 658
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Received |
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2021-04-30 12:11 |
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Peer-Review Started |
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2021-04-30 12:14 |
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To Make the First Decision |
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Return for Revision |
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2021-06-20 09:45 |
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Revised |
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2021-06-23 16:10 |
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Second Decision |
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2021-09-03 03:06 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2021-09-03 10:36 |
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Articles in Press |
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2021-09-03 10:36 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-10-20 01:32 |
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Publish the Manuscript Online |
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2021-10-22 13:53 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Acute liver failure with hemolytic anemia in children with Wilson’s disease: Genotype-phenotype correlations?
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Tudor Lucian Pop, Alina Grama, Ana Cristina Stefanescu, Claudia Willheim and Peter Ferenci |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Tudor Lucian Pop, MD, PhD, Associate Professor, 2nd Pediatric Discipline, Department of Mother and Child, Iuliu Hatieganu University of Medicine and Pharmacy, Str. Crisan nr 5, Cluj-Napoca 400177, Romania. tudor.pop@umfcluj.ro |
| Key Words |
Wilson’s disease; Children; Acute liver failure; Hemolytic anemia; ATP7B variant; Genotype-phenotype correlation |
| Core Tip |
Acute liver failure (ALF) and hemolytic anemia represent the most severe presentation of Wilson’s disease (WD) in children, with a possible fatal evolution. There is no definite genotype-phenotype correlation in WD, but many studies try to solve this puzzle. Our research reports a higher presence of a missense [p.Trp939Cys (c.2817G>T)] and frame-shift variant [p.Lys844Ter (c.2530A>T)] in children with ALF and hemolytic anemia, while in less severe form, p.His1069Gln (c.3207A>G) was more frequent. HSD17B13:TA variant may be associated with less severe liver disease, as it was proved to have a protective role against liver toxins. |
| Publish Date |
2021-10-22 13:53 |
| Citation |
Pop TL, Grama A, Stefanescu AC, Willheim C, Ferenci P. Acute liver failure with hemolytic anemia in children with Wilson’s disease: Genotype-phenotype correlations? World J Hepatol 2021; 13(10): 1428-1438 |
| URL |
https://www.wjgnet.com/1948-5182/full/v13/i10/1428.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v13.i10.1428 |
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