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Articles Published Processes
1/21/2022 8:16:14 AM | Browse: 552 | Download: 1156
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Received |
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2021-05-03 10:39 |
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Peer-Review Started |
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2021-05-03 10:43 |
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To Make the First Decision |
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Return for Revision |
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2021-06-15 21:49 |
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Revised |
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2021-06-18 04:12 |
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Second Decision |
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2021-12-09 03:41 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-12-10 03:11 |
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Articles in Press |
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2021-12-10 03:11 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-12-07 10:40 |
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Typeset the Manuscript |
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2022-01-18 04:33 |
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Publish the Manuscript Online |
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2022-01-21 08:16 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Minireviews |
| Article Title |
Stearoyl-CoA desaturase 1: A potential target for non-alcoholic fatty liver disease?-perspective on emerging experimental evidence
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Shanmugam Murugaiha Jeyakumar and Ayyalasomayajula Vajreswari |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Indian Council of Medical Research (ICMR) |
5/4/3-10/TF/2011/NCD-II |
| Department of Biotechnology (DBT) |
BT/PR6145/FNS/20/566/2012 |
| ICMR-NIN-Intramural Gran |
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| Corresponding Author |
Shanmugam Murugaiha Jeyakumar, PhD, Senior Scientist, Department of Clinical Pharmacology, National Institute for Research in Tuberculosis, No. 1 Mayor Sathiyamoorthy Road, Chetpet, Chennai 600031, Tamil Nadu, India. smjkumar@gmail.com |
| Key Words |
Steatosis; Lipids; Fatty acids; Vitamin A; Metabolic syndrome; Obesity |
| Core Tip |
Stearoyl-CoA desaturase 1 (SCD1) is the rate-limiting enzyme of the monounsaturated fatty acids biosynthesis that serves as substrates for de novo lipogenesis, thereby increasing the production and accumulation of triglycerides in the liver. The liver-specific inhibition of SCD1 has been shown to attenuate the development of hepatic steatosis and thus non-alcoholic fatty liver disease (NAFLD), as evidenced by experimental studies. The current evidence supports the view that SCD1 is a potential target and the inhibition of this enzyme would certainly help in the control and/or management of NAFLD in humans. However, certain aspects of SCD1 such as its role and regulation need to be addressed in humans to explore its potential translational applicability. |
| Publish Date |
2022-01-21 08:16 |
| Citation |
Jeyakumar SM, Vajreswari A. Stearoyl-CoA desaturase 1: A potential target for non-alcoholic fatty liver disease?-perspective on emerging experimental evidence. World J Hepatol 2022; 14(1): 168-179 |
| URL |
https://www.wjgnet.com/1948-5182/full/v14/i1/168.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v14.i1.168 |
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