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Articles Published Processes
8/5/2021 2:37:06 PM | Browse: 375 | Download: 875
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Received |
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2021-05-06 05:05 |
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Peer-Review Started |
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2021-05-06 05:08 |
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To Make the First Decision |
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Return for Revision |
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2021-06-06 16:40 |
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Revised |
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2021-06-08 15:30 |
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Second Decision |
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2021-06-22 06:17 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-06-22 09:50 |
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Articles in Press |
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2021-06-22 09:50 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-06-28 02:25 |
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Typeset the Manuscript |
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2021-08-02 07:39 |
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Publish the Manuscript Online |
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2021-08-05 14:37 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Report |
| Article Title |
Sirolimus treatment for neonate with blue rubber bleb nevus syndrome: A case report
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Si-Si Yang, Ming Yang, Xiao-Jie Yue and Jin-Fa Tou |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Jin-Fa Tou, PhD, Chief Doctor, Professor, Department of Neonatal Surgery, The Children's Hospital of University of Zhejiang Medicine School, No. 3333 Binsheng Road, Hangzhou 310000, Zhejiang Province, China. toujinfa@zju.edu.cn |
| Key Words |
Cutaneous hemangioma; Vascular malformation; Sirolimus; Rapamycin; Blue rubber bleb nevus syndrome; Case report |
| Core Tip |
Sirolimus is considered as a first-line drug in treating patients with blue rubber bleb naevus syndrome currently. We present herein, the youngest age of medication of successful, long-term treatment with sirolimus. This case finds two situations, firstly the recommended doses of 0.1 mg/kg/d resulted with plasma concentration was far beyond the expected of 10-15 ng/mL in neonates, secondly a high plasma concentration of more than 20 ng/mL is associated with a great improvement in the condition. We highlight the dosing regimen and plasma concentration is special in neonates. |
| Publish Date |
2021-08-05 14:37 |
| Citation |
Yang SS, Yang M, Yue XJ, Tou JF. Sirolimus treatment for neonate with blue rubber bleb nevus syndrome: A case report. World J Clin Cases 2021; 9(23): 6929-6934 |
| URL |
https://www.wjgnet.com/2307-8960/full/v9/i23/6929.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v9.i23.6929 |
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