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Articles Published Processes
9/17/2021 8:43:53 AM | Browse: 436 | Download: 1014
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Received |
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2021-05-03 13:45 |
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Peer-Review Started |
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2021-05-03 13:47 |
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To Make the First Decision |
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Return for Revision |
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2021-06-16 04:35 |
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Revised |
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2021-06-19 12:06 |
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Second Decision |
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2021-07-30 03:30 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-07-30 08:06 |
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Articles in Press |
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2021-07-30 08:06 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-08-09 21:18 |
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Typeset the Manuscript |
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2021-09-16 05:17 |
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Publish the Manuscript Online |
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2021-09-17 08:43 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Hematopoietic stem cell mobilization strategies to support high-dose chemotherapy: A focus in relapsed/refractory germ-cell tumors
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Eleni Porfyriou, Sylvia Letsa and Christos Kosmas |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Eleni Porfyriou, MD, Doctor, Doctor, Department of Medical Oncology and Hematopoietic Cell Transplant Unit, “Metaxa” Cancer Hospital, 51 Botassi Street, Piraeus 18537, Greece. porfyriou7@gmail.com |
| Key Words |
Hematopoietic stem cells; Germ-cell tumors; Hematopoietic stem cell transplantation; Granulocyte-colony-stimulating factor; Plerixafor |
| Core Tip |
High-dose chemotherapy (HDCT) followed by autologous stem cell transplantation (ASCT) represents a curative treatment option for patients with relapsed/refractory germ-cell tumors (GCTs). Mobilization of adequate numbers of hematopoietic stem cells (HSCs) is a prerequisite for successful ASCT. As the benefit of HDCT+ASCT is largely evident with > one HDCT cycle, it is anticipated that an appreciable percentage of patients will not mobilize adequate HSCs and require salvage strategies. Herein, we review the history of HSC transplantation, with emphasis in GCTs, pathophysiological mechanisms of HSC mobilization, initial and salvage mobilization strategies, and finally discuss novel mobilizing agents and approaches to overcome failures. |
| Publish Date |
2021-09-17 08:43 |
| Citation |
Porfyriou E, Letsa S, Kosmas C. Hematopoietic stem cell mobilization strategies to support high-dose chemotherapy: A focus in relapsed/refractory germ cell tumors. World J Clin Oncol 2021; 12(9): 746-766 |
| URL |
https://www.wjgnet.com/2218-4333/full/v12/i9/746.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v12.i9.746 |
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