Publication Name	World Journal of Gastroenterology
Manuscript ID	6792
Country	Japan

Received	2013-11-01 11:26
Peer-Review Started	2013-11-01 20:06
To Make the First Decision	2013-12-26 11:05
Return for Revision	2013-12-27 21:51
Revised	2014-01-08 15:52
Second Decision	2014-02-17 16:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-02-17 17:00
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-03-26 19:04
Publish the Manuscript Online	2014-04-14 10:49

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	DNA methylation in gastric cancer, related to Helicobacter pylori and Epstein-Barr virus
Manuscript Source	Invited Manuscript
All Author List	Keisuke Matsusaka, Sayaka Funata, Masashi Fukayama and Atsushi Kaneda
Funding Agency and Grant Number
Corresponding Author	Atsushi Kaneda, MD, PhD, Department of Molecular Oncology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba-City 260-8670, Japan. kaneda@chiba-u.jp
Key Words	Gastric cancer; Epigenetics; DNA methylation; Epstein-Barr virus; Helicobacter pylori
Core Tip	Recent technological advances in genome-wide analysis tools have revealed various molecular aberrations in cancer. Although gastric cancer involves multiple genetic and epigenetic alterations, aberrant DNA methylation in gene promoter regions is thought to play a critical role in gastric carcinogenesis. From the etiological viewpoint, two pathogens, Helicobacter pylori (H. pylori) and Epstein-Barr virus (EBV), are known to participate in gastric carcinogenesis. Chronic inflammation in the gastric mucosa due to H. pylori and EBV infection of gastric epithelial cells has been reported to cause aberrant promoter methylation, which may contribute to the tumorigenic mechanisms of these pathogens.
Publish Date	2014-04-14 10:49
Citation	Matsusaka K, Funata S, Fukayama M, Kaneda A. DNA methylation in gastric cancer, related to Helicobacter pylori and Epstein-Barr virus. World J Gastroenterol 2014; 20(14): 3916-3926
URL	http://www.wjgnet.com/1007-9327/full/v20/i14/3916.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i14.3916

Full Article (PDF)	WJG-20-3916.pdf
Full Article (Word)	WJG-20-3916.doc
Manuscript File	6792-Review.doc
Answering Reviewers	6792-Answering reviews.pdf
Copyright License Agreement	6792-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	6792-Scientific editor work list.doc
Peer-review Report	6792-Peer review(s).pdf
Scientific Editor Work List	6792-Scientific editor work list.doc