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Articles Published Processes
8/28/2014 9:54:00 AM | Browse: 1067 | Download: 1136
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Received |
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2013-10-29 10:32 |
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Peer-Review Started |
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2013-10-30 07:51 |
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To Make the First Decision |
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2013-12-16 17:35 |
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Return for Revision |
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2013-12-17 19:29 |
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Revised |
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2014-01-02 21:38 |
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Second Decision |
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2014-02-17 16:44 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-02-17 17:00 |
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Articles in Press |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2014-03-18 22:17 |
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Typeset the Manuscript |
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2014-04-24 17:53 |
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Publish the Manuscript Online |
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2014-05-14 10:58 |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Topic Highlights |
| Article Title |
Hepatitis B virus genetic mutations and evolution in liver diseases
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Tao Shen and Xin-Min Yan |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81160352 |
| Health Bureau of Yunnan Province (in part) |
D-201203 |
| Science and Technology Department of Yunnan Province (in part) |
2013HB084 |
| Special fund of Science and Technology Department of Yunnan Province (in part) |
2012WS0072 |
| Hospital Science Foundation of the First People’s Hospital of Yunnan Province (2007) (in part) |
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| Corresponding Author |
Shen Tao, Associate Professor, Center of Clinical Molecular Biology, Provincial Key Laboratory for Birth Defects and Genetic Diseases, the First People’s Hospital of Yunnan Province, Affiliated Hospital of Kumning Science and Technology University, 157 JinBi Road, Kunming 650032, Yunnan Province, China. ts902@126.com |
| Key Words |
Hepatitis B virus; Mutation; Genotype; Liver disease; Risk markers |
| Core Tip |
Understanding the characteristics of hepatitis B virus (HBV) is crucial for early diagnosis and optimized treatment. In this review, we reviewed the technologies being used in the evolutionary and mutational analysis of HBV and introduced a high throughput method of deep sequencing for HBV (ultra-high-throughput next generation sequencing technology). And then, we separately discussed the correlation between HBV genomic mutations in four open reading frames and liver disease progression. Since some of the results were controversial from different laboratories, it remains to be seen whether functional analyses will confirm their role in modifying the course of infection. |
| Publish Date |
2014-05-14 10:58 |
| Citation |
Shen T, Yan XM. Hepatitis B virus genetic mutations and evolution in liver diseases. World J Gastroenterol 2014; 20(18): 5435-5441 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i18/5435.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i18.5435 |
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