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Articles Published Processes
8/28/2014 5:50:00 PM | Browse: 796 | Download: 926
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Received |
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2013-10-29 10:45 |
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Peer-Review Started |
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2013-10-30 08:07 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2013-11-14 19:26 |
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Revised |
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2013-12-12 13:54 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2014-03-10 15:09 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2014-03-10 17:02 |
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Articles in Press |
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Edit the Manuscript by Language Editor |
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2014-03-27 01:42 |
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Typeset the Manuscript |
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2014-04-22 08:55 |
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Publish the Manuscript Online |
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2014-04-29 09:53 |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Topic Highlights |
| Article Title |
Ethnic differences in gastric cancer genetic susceptibility: Allele flips of interleukin gene
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Juwon Kim, Yoonjung Kim and Kyung-A Lee |
| Funding Agency and Grant Number |
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| Corresponding Author |
Kyung-A Lee, MD, PhD, Department of Laboratory Medicine, Yonsei University College of Medicine, 211 Eonju-ro, Gangnam-gu, Seoul 135-720, South Korea. kal1119@yuhs.ac |
| Key Words |
Allele flip; Gastric cancer; Interleukin gene |
| Core Tip |
In Asian populations, the highly expressed interleukin (IL)-1β haplotype may increase risk for gastric cancer. Abundant IL-1β expression determined by this haplotype may suppress gastric acid production in response to chronic Helicobacter pylori (H. pylori) infection, resulting in atrophic gastritis, the precursor of non-cardia gastric cancer. Conversely, the less expressive IL-1β haplotype associates with gastric cardia cancer in Caucasians. Only low levels of IL-1β are produced in response to H. pylori infection and gastric acid secretion is increased. Induction of gastroesophageal reflux disease may then promote cardia cancers. |
| Publish Date |
2014-04-29 09:53 |
| Citation |
Kim J, Kim Y, Lee KA. Ethnic differences in gastric cancer genetic susceptibility: Allele flips of interleukin gene. World J Gastroenterol 2014; 20(16): 4558-4565
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| URL |
http://www.wjgnet.com/1007-9327/full/v20/i16/4558.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i16.4558 |
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