Publication Name	World Journal of Gastroenterology
Manuscript ID	6800
Country	South Korea

Received	2013-10-29 10:45
Peer-Review Started	2013-10-30 08:07
First Decision by Editorial Office Director
Return for Revision	2013-11-14 19:26
Revised	2013-12-12 13:54
Publication Fee Transferred
Second Decision by Editor	2014-03-10 15:09
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-03-10 17:02
Articles in Press
Edit the Manuscript by Language Editor	2014-03-27 01:42
Typeset the Manuscript	2014-04-22 08:55
Publish the Manuscript Online	2014-04-29 09:53

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Ethnic differences in gastric cancer genetic susceptibility: Allele flips of interleukin gene
Manuscript Source	Invited Manuscript
All Author List	Juwon Kim, Yoonjung Kim and Kyung-A Lee
Funding Agency and Grant Number
Corresponding Author	Kyung-A Lee, MD, PhD, Department of Laboratory Medicine, Yonsei University College of Medicine, 211 Eonju-ro, Gangnam-gu, Seoul 135-720, South Korea. kal1119@yuhs.ac
Key Words	Allele flip; Gastric cancer; Interleukin gene
Core Tip	In Asian populations, the highly expressed interleukin (IL)-1β haplotype may increase risk for gastric cancer. Abundant IL-1β expression determined by this haplotype may suppress gastric acid production in response to chronic Helicobacter pylori (H. pylori) infection, resulting in atrophic gastritis, the precursor of non-cardia gastric cancer. Conversely, the less expressive IL-1β haplotype associates with gastric cardia cancer in Caucasians. Only low levels of IL-1β are produced in response to H. pylori infection and gastric acid secretion is increased. Induction of gastroesophageal reflux disease may then promote cardia cancers.
Publish Date	2014-04-29 09:53
Citation	Kim J, Kim Y, Lee KA. Ethnic differences in gastric cancer genetic susceptibility: Allele flips of interleukin gene. World J Gastroenterol 2014; 20(16): 4558-4565
URL	http://www.wjgnet.com/1007-9327/full/v20/i16/4558.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i16.4558

Full Article (PDF)	WJG-20-4558.pdf
Full Article (Word)	WJG-20-4558.doc
Manuscript File	6800-Review.doc
Answering Reviewers	6800-Answering reviewers.pdf
Copyright License Agreement	6800-Copyright assignment.pdf
Peer-review Report	6800-Peer review(s).pdf
Scientific Editor Work List	6800-Scientific editor work list.doc