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Articles Published Processes
10/28/2021 3:02:02 AM | Browse: 712 | Download: 1215
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Received |
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2021-05-09 20:09 |
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Peer-Review Started |
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2021-05-09 20:12 |
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To Make the First Decision |
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Return for Revision |
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2021-07-27 06:29 |
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Revised |
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2021-08-16 12:28 |
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Second Decision |
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2021-10-15 06:33 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-10-15 08:53 |
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Articles in Press |
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2021-10-15 08:53 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-09-30 23:41 |
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Typeset the Manuscript |
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2021-10-26 07:03 |
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Publish the Manuscript Online |
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2021-10-28 03:02 |
| ISSN |
2219-2824 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Opinion Review |
| Article Title |
Interactions between human microbiome, liver diseases, and immunosuppression after liver transplant
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Milena Peruhova, Monika Peshevska-Sekulovska and Tsvetelina Velikova |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Milena Peruhova, MD, Assistant Professor, Chief Doctor, Department of Gastroenterology, University Hospital Lozenetz, Kozyak 1 str., Sofia 1407, Bulgaria. mperuhova@gmail.com |
| Key Words |
Liver transplantation; De novo malignancy; Immunosuppressive therapy; Calcineurin inhibitors; Tacrolimus; Cyclosporine; Microbiome; Carcinogenesis; Immune tolerance |
| Core Tip |
It was estimated that liver transplant recipients have a higher risk of developing de novo malignancy (DNM) compared to the general population. Immunosuppressive (IS) therapy used after liver transplantation (LT) is one of the substantial risk factors for the development of DNM. Tumorigenesis and tumor growth in LT patients are linked with the length of IS therapy's administration and intensity. Recent data showed that the microbiota could significantly affect the survival and acceptance of transplanted allographs. This once again indicates the incredibly complex interaction between the immune system and microbiome in the settings of LT and raises the possible strategies to induce immunotolerance and reduce the complications such as DNM. |
| Publish Date |
2021-10-28 03:02 |
| Citation |
Peruhova M, Peshevska-Sekulovska M, Velikova T. Interactions between human microbiome, liver diseases, and immunosuppression after liver transplant. World J Immunol 2021; 11(2): 11-16 |
| URL |
https://www.wjgnet.com/2219-2824/full/v11/i2/11.htm |
| DOI |
https://dx.doi.org/10.5411/wji.v11.i2.11 |
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