Publication Name	World Journal of Clinical Oncology
Manuscript ID	68036
Country	Peru

Received	2021-05-10 03:09
Peer-Review Started	2021-05-10 03:12
To Make the First Decision
Return for Revision	2021-06-05 13:59
Revised	2021-06-18 23:32
Second Decision	2021-07-12 03:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-07-12 06:30
Articles in Press	2021-07-12 06:30
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-07-21 06:55
Typeset the Manuscript	2021-08-20 03:25
Publish the Manuscript Online	2021-08-23 06:43

ISSN	2218-4333 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Case Report
Article Title	PIK3CA mutation in non-metastatic triple-negative breast cancer as a potential biomarker of early relapse: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Guillermo Arturo Valencia, Patricia Rioja, Zaida Morante, Jhajaira M Araujo, Heberth Daniel Vallejos, Henry Guerra and Henry L Gomez
ORCID	Author(s) ORCID Number Guillermo Arturo Valencia http://orcid.org/0000-0002-4234-4448 Patricia Rioja http://orcid.org/0000-0003-3141-7418 Zaida Morante http://orcid.org/0000-0001-9725-9278 Jhajaira M Araujo http://orcid.org/0000-0002-9639-8070 Heberth Daniel Vallejos http://orcid.org/0000-0002-0517-0979 Henry Guerra http://orcid.org/0000-0002-4894-5631 Henry L Gomez http://orcid.org/0000-0003-2660-1843
Funding Agency and Grant Number
Corresponding Author	Guillermo Arturo Valencia, MD, Medical Assistant, Medical Oncology, Instituto Nacional de Enfermedades Neoplásicas, Angamos Este Avenue 2520. Surquillo, Lima 15000, Peru. guillermo.valencia.mesias@gmail.com
Key Words	Triple-negative breast cancer; PIK3CA mutation; Liquid biopsy; Early relapse; Biomarker; Case report
Core Tip	This case report evaluates the detection of PIK3CA mutation in liquid biopsy and tumor tissue in a patient with locally-advanced triple-negative breast cancer after receiving conventional oncological therapy and its association with early relapse and progression disease. This case highlights the importance of detecting the PIK3CA mutation as a potential biomarker of early relapse. In addition, the PIK3CA mutation could lead to additional interventions to detect metastatic disease earlier in the follow-up. There is limited information of liquid biopsy studies after surgery. Furthermore, there is very limited data about trials of PIK3CA mutations in Peruvian patients with non-metastatic breast cancer.
Publish Date	2021-08-23 06:43
Citation	Valencia GA, Rioja P, Morante Z, Araujo JM, Vallejos HD, Guerra H, Gomez HL. PIK3CA mutation in non-metastatic triple-negative breast cancer as a potential biomarker of early relapse: A case report. World J Clin Oncol 2021; 12(8): 702-711
URL	https://www.wjgnet.com/2218-4333/full/v12/i8/702.htm
DOI	https://dx.doi.org/10.5306/wjco.v12.i8.702

Full Article (PDF)	WJCO-12-702.pdf
Full Article (Word)	WJCO-12-702.docx
CARE Checklist–2016	68036-CARE-Checklist–2016-revision.pdf
Manuscript File	68036-Review-Filipodia.docx
Answering Reviewers	68036-Answering reviewers.pdf
Audio Core Tip	68036-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	68036-Conflict-of-interest statement.pdf
Copyright License Agreement	68036-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	68036-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	68036-Language certificate.pdf
Peer-review Report	68036-Peer-review(s).pdf
Scientific Misconduct Check	68036-Bing-Wang LL-2.png
Scientific Misconduct Check	68036-Scientific misconduct check.pdf
Scientific Editor Work List	68036-Scientific editor work list.pdf