Publication Name	World Journal of Gastroenterology
Manuscript ID	6811
Country	Japan

Received	2013-10-29 11:22
Peer-Review Started	2013-10-29 20:23
To Make the First Decision	2013-12-04 08:51
Return for Revision	2013-12-04 19:36
Revised	2014-01-17 16:59
Second Decision	2014-02-20 09:07
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-02-20 09:27
Articles in Press	2014-05-23 11:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-05-29 12:33
Publish the Manuscript Online	2014-06-16 16:19

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Autobiography
Article Title	Role of the Na+/K+/2Cl- cotransporter NKCC1 in cell cycle progression in human esophageal squamous cell carcinoma
Manuscript Source	Invited Manuscript
All Author List	Atsushi Shiozaki, Yoshito Nako, Daisuke Ichikawa, Hirotaka Konishi, Shuhei Komatsu, Takeshi Kubota, Hitoshi Fujiwara, Kazuma Okamoto, Mitsuo Kishimoto, Yoshinori Marunaka and Eigo Otsuji
Funding Agency and Grant Number	Funding Agency Grant Number Grants-in-Aid for Young Scientists (B) from the Japan Society for the Promotion of Science 22791295 Grants-in-Aid for Young Scientists (B) from the Japan Society for the Promotion of Science 23791557 Grants-in-Aid for Young Scientists (B) from the Japan Society for the Promotion of Science 24791440 Grant-in-Aid for Scientific Research (C) from the Japan Society for the Promotion of Science 22591464 Grant-in-Aid for Scientific Research (C) from the Japan Society for the Promotion of Science 24591957
Corresponding Author	Atsushi Shiozaki, Assistant Professor, Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, Japan. shiozaki@koto.kpu-m.ac.jp
Key Words	Na+/K+/2Cl- cotransporter 1; Esophageal cancer; Cell cycle
Core Tip	The objectives of the present study were to investigate the role of Na+/K+/2Cl- cotransporter 1 (NKCC1) in the regulation of genes involved in cell cycle progression and the clinicopathological significance of its expression in esophageal squamous cell carcinoma (ESCC). An immunohistochemical analysis revealed that the expression of NKCC1 in ESCC samples was related to the histological type. Microarray results suggested that NKCC1 exhibits marked effects on the expression of genes related to G2/M cell cycle progression. A deeper understanding of the role of NKCC1 may lead to its use as an important biomarker and/or a novel therapeutic target for ESCC treatment.
Publish Date	2014-06-16 16:19
Citation	Shiozaki A, Nako Y, Ichikawa D, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Marunaka Y, Otsuji E. Role of the Na+/K+/2Cl- cotransporter NKCC1 in cell cycle progression in human esophageal squamous cell carcinoma. World J Gastroenterol 2014; 20(22): 6844-6859
URL	http://www.wjgnet.com/1007-9327/full/v20/i22/6844.htm
DOI	10.3748/wjg.v20.i22.6844

Full Article (PDF)	WJG-20-6844.pdf
Full Article (Word)	WJG-20-6844.doc
Manuscript File	6811-Review.docx
Answering Reviewers	6811-Answering reviewers.pdf
Copyright License Agreement	6811-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	6811-Language certificate.pdf
Peer-review Report	6811-Peer review(s).pdf
Scientific Editor Work List	6811-Scientific editor work list.doc