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Articles Published Processes
10/26/2021 3:59:25 AM | Browse: 413 | Download: 953
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Received |
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2021-05-17 00:42 |
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Peer-Review Started |
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2021-05-17 00:45 |
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To Make the First Decision |
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Return for Revision |
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2021-06-16 03:47 |
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Revised |
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2021-06-23 06:50 |
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Second Decision |
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2021-09-17 03:30 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-09-19 09:06 |
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Articles in Press |
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2021-09-19 09:06 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-10-22 09:32 |
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Publish the Manuscript Online |
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2021-10-26 03:59 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Review |
| Article Title |
Age and genotype dependent erythropoietin protection in COVID-19
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Konstantinos I Papadopoulos, Warachaya Sutheesophon, Somjate Manipalviratn and Tar-Choon Aw |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Konstantinos I Papadopoulos, MD, PhD, Chairman, Chief Doctor, Director, Director, Department of Research and Development, THAI StemLife, 566/3 Soi Ramkhamhaeng 39 (Thepleela 1), Prachaouthit Road, Wangthonglang, Bangkok 10310, Thailand. kostas@thaistemlife.co.th |
| Key Words |
Erythropoietin; Angiotensin converting enzyme; Angiotensin II; Hemoglobinopathy; Malaria; Coronavirus disease 2019; Fibroblast growth factor 23 |
| Core Tip |
Erythropoietin (EPO) appears to mediate an ancestral neuroprotective innate immune response mechanism mitigating tissue injury and pathogen invasion at an early age. Age-dependent but anemia-unrelated EPO elevation has been reported in conditions that threaten the young brain such as prematurity, incipient kernicterus, and malaria. Malaria protective genetic determinants such as the angiotensin converting enzyme (ACE) D allele and the thalassemias can raise EPO and extend their protection against coronavirus disease 2019 in an age-dependent manner but could turn detrimental in genetically predisposed adults. ACE2 could represent a “bait” for severe acute respiratory syndrome coronavirus-2 to induce ACE/ACE2 imbalance and angiotensin II engendered protective EPO increase at a young age irrespective of genetic predisposition. |
| Publish Date |
2021-10-26 03:59 |
| Citation |
Papadopoulos KI, Sutheesophon W, Manipalviratn S, Aw T. Age and genotype dependent erythropoietin protection in COVID-19. World J Stem Cells 2021; 13(10): 1513-1529 |
| URL |
https://www.wjgnet.com/1948-0210/full/v13/i10/1513.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v13.i10.1513 |
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