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8/29/2014 2:41:00 PM | Browse: 401 | Download: 435
Publication Name World Journal of Gastroenterology
Manuscript ID 6823
Country/Territory Japan
Received
2013-10-29 12:12
Peer-Review Started
2013-10-29 19:10
To Make the First Decision
2013-12-16 17:33
Return for Revision
2013-12-17 19:37
Revised
2014-01-15 13:37
Second Decision
2014-03-10 13:29
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-03-10 17:21
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-03-26 19:04
Publish the Manuscript Online
2014-04-14 10:49
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Topic Highlights
Article Title Updated review of gastric cancer in the next-generation sequencing era: Insights from bench to bedside and vice versa
Manuscript Source Invited Manuscript
All Author List Hiroyuki Yamamoto, Yoshiyuki Watanabe, Tadateru Maehata, Ryo Morita, Yoshihito Yoshida, Ritsuko Oikawa, Shinya Ishigooka, Shun-ichiro Ozawa, Yasumasa Matsuo, Kosuke Hosoya, Masaki Yamashita, Hiroaki Taniguchi, Katsuhiko Nosho, Hiromu Suzuki, Hiroshi Yasuda, Yasuhisa Shinomura and Fumio Itoh
Funding Agency and Grant Number
Funding Agency Grant Number
Ministry of Education, Culture, Sports, Science and Technology of Japan
Corresponding author Hiroyuki Yamamoto, MD, FJSIM, PhD, Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine, Sugo 2-16-1 Miyamae, Kawasaki 216-8511, Japan. h-yama@marianna-u.ac.jp
Keywords Next-generation sequencing; Microsatellite instability; MicroRNA; Epigenetic field defect; Gastric washes; Insulin-like growth factor 1 receptor
Core Tip The genetic and epigenetic alterations in gastric cancers (GC) have biological and clinical implications. Recent advances in the molecular research of GC have introduced new diagnostic and therapeutic strategies to clinical settings. In this review, we summarize the key findings of past reports pertaining to the genetics and epigenetics of GC and their relationship to and future applications in next-generation sequencing (NGS). We also describe the recurrently mutated genes and alterations in GC identified by NGS technology and discuss the basic framework for future investigations, including the challenges of using NGS as a tool for biomarker and therapeutic target discovery.
Publish Date 2014-04-14 10:49
Citation Yamamoto H, Watanabe Y, Maehata T, Morita R, Yoshida Y, Oikawa R, Ishigooka S, Ozawa S, Matsuo Y, Hosoya K, Yamashita M, Taniguchi H, Nosho K, Suzuki H, Yasuda H, Shinomura Y, Itoh F. An updated review of gastric cancer in the next-generation sequencing era: Insights from bench to bedside and vice versa. World J Gastroenterol 2014; 20(14): 3927-3937
Url http://www.wjgnet.com/1007-9327/full/v20/i14/3927.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i14.3927
Full Article (PDF) WJG-20-3927.pdf
Full Article (Word) WJG-20-3927.doc
Manuscript File 6823-Review.doc
Answering Reviewers 6823-Answering reviewers.pdf
Copyright License Agreement 6823-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 6823-Language certificate.pdf
Peer-review Report 6823-Peer review(s).pdf
Scientific Editor Work List 6823-Scientific editor work list.doc