| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Topic Highlights |
| Article Title |
Updated review of gastric cancer in the next-generation sequencing era: Insights from bench to bedside and vice versa
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Hiroyuki Yamamoto, Yoshiyuki Watanabe, Tadateru Maehata, Ryo Morita, Yoshihito Yoshida, Ritsuko Oikawa, Shinya Ishigooka, Shun-ichiro Ozawa, Yasumasa Matsuo, Kosuke Hosoya, Masaki Yamashita, Hiroaki Taniguchi, Katsuhiko Nosho, Hiromu Suzuki, Hiroshi Yasuda, Yasuhisa Shinomura and Fumio Itoh |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Ministry of Education, Culture, Sports, Science and Technology of Japan |
|
|
| Corresponding Author |
Hiroyuki Yamamoto, MD, FJSIM, PhD, Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine, Sugo 2-16-1 Miyamae, Kawasaki 216-8511, Japan. h-yama@marianna-u.ac.jp |
| Key Words |
Next-generation sequencing; Microsatellite instability; MicroRNA; Epigenetic field defect; Gastric washes; Insulin-like growth factor 1 receptor |
| Core Tip |
The genetic and epigenetic alterations in gastric cancers (GC) have biological and clinical implications. Recent advances in the molecular research of GC have introduced new diagnostic and therapeutic strategies to clinical settings. In this review, we summarize the key findings of past reports pertaining to the genetics and epigenetics of GC and their relationship to and future applications in next-generation sequencing (NGS). We also describe the recurrently mutated genes and alterations in GC identified by NGS technology and discuss the basic framework for future investigations, including the challenges of using NGS as a tool for biomarker and therapeutic target discovery. |
| Publish Date |
2014-04-14 10:49 |
| Citation |
Yamamoto H, Watanabe Y, Maehata T, Morita R, Yoshida Y, Oikawa R, Ishigooka S, Ozawa S, Matsuo Y, Hosoya K, Yamashita M, Taniguchi H, Nosho K, Suzuki H, Yasuda H, Shinomura Y, Itoh F. An updated review of gastric cancer in the next-generation sequencing era: Insights from bench to bedside and vice versa. World J Gastroenterol 2014; 20(14): 3927-3937 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i14/3927.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i14.3927 |
