Publication Name	World Journal of Gastroenterology
Manuscript ID	6826
Country	Poland

Received	2013-10-29 12:23
Peer-Review Started	2013-10-29 20:22
To Make the First Decision	2013-12-03 18:52
Return for Revision	2013-12-05 15:22
Revised	2013-12-25 22:30
Second Decision	2014-01-05 14:59
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-01-05 15:16
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-02-25 13:23
Publish the Manuscript Online	2014-03-06 14:13

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Biochemistry & Molecular Biology
Manuscript Type	Topic Highlights
Article Title	Role of abnormal lipid metabolism in development, progression, diagnosis and therapy of pancreatic cancer
Manuscript Source	Invited Manuscript
All Author List	Julian Swierczynski, Areta Hebanowska and Tomasz Sledzinski
Funding Agency and Grant Number	Funding Agency Grant Number Medical University of Gdansk ST-41 Medical University of Gdansk ST-40
Corresponding Author	Julian Swierczynski, Professor, Department of Biochemistry, Medical University of Gdansk, ul. Debinki 1, 80-211 Gdansk, Poland. juls@gumed.edu.pl
Key Words	Pancreatic cancer; Lipid metabolism; Fatty acid synthase; Monounsaturated fatty acids; Farnesylation; Hypoxia inducible factor 1α; Cyclooxygenase-2; Oncogenes; Tumor suppressors; Lipogenic enzymes inhibitors
Core Tip	Metabolic alterations associated with mutation in oncogenes and tumor suppressor genes play an important role in cancer development and progression. One of the most important aberrations of metabolism in cancer cells is an elevated synthesis of lipids, which are building blocks for cell membrane formation during cell proliferation and signalling molecules. This review aims to demonstrate the changes in lipid metabolism in pancreatic ductal adenocarcinoma, the most common pancreatic neoplasm, with very high mortality. The potential role of elevated lipid synthesis in diagnosis, prognosis and therapy of pancreatic cancer is also discussed.
Publish Date	2014-03-06 14:13
Citation	Swierczynski J, Hebanowska A, Sledzinski T. Role of abnormal lipid metabolism in development, progression, diagnosis and therapy of pancreatic cancer. World J Gastroenterol 2014; 20(9): 2279-2303
URL	http://www.wjgnet.com/1007-9327/full/v20/i9/2279.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i9.2279

Full Article (PDF)	WJG-20-2279.pdf
Full Article (Word)	WJG-20-2279.doc
Manuscript File	6826-Review.doc
Answering Reviewers	6826-Answering reviewers.pdf
Copyright License Agreement	6826-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	6826-Language certificate.pdf
Peer-review Report	6826-Peer review(s).pdf
Scientific Editor Work List	6826-Scientific editor work list.doc