Publication Name	World Journal of Gastroenterology
Manuscript ID	68269
Country	China

Received	2021-05-19 15:32
Peer-Review Started	2021-05-19 15:34
To Make the First Decision
Return for Revision	2021-06-22 19:21
Revised	2021-07-05 15:11
Second Decision	2021-09-13 02:26
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-09-16 23:48
Articles in Press	2021-09-16 23:48
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-10-22 05:49
Typeset the Manuscript	2021-11-16 10:26
Publish the Manuscript Online	2021-11-19 11:15

ISSN	1007-9327 (print) and 2219-2840 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Genome-wide map of N6-methyladenosine circular RNAs identified in mice model of severe acute pancreatitis
Manuscript Source	Unsolicited Manuscript
All Author List	Jun Wu, Xiao-Hui Yuan, Wen Jiang, Yi-Chen Lu, Qi-Lin Huang, Yi Yang, Hua-Ji Qie, Jiang-Tao Liu, Hong-Yu Sun and Li-Jun Tang
ORCID	Author(s) ORCID Number Jun Wu http://orcid.org/0000-0003-1555-8026 Xiao-Hui Yuan http://orcid.org/0000-0002-6462-2672 Wen Jiang http://orcid.org/0000-0001-6823-6122 Yi-Chen Lu http://orcid.org/0000-0002-4020-4847 Qi-Lin Huang http://orcid.org/0000-0002-0819-4829 Yi Yang http://orcid.org/0000-0002-0189-6246 Hua-Ji Qie http://orcid.org/0000-0002-6648-7339 Jiang-Tao Liu http://orcid.org/0000-0002-5993-8103 Hong-Yu Sun http://orcid.org/0000-0002-8587-0499 Li-Jun Tang http://orcid.org/0000-0001-6000-9515
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81772001 National Clinical Key Subject of China 41792113
Corresponding Author	Li-Jun Tang, MD, PhD, Chief Doctor, Professor, Department of General Surgery and Pancreatic Injury and Repair Key Laboratory of Sichuan Province, The General Hospital of Western Theater Command, No. 270 Tianhuan Road, Furong Avenue, Jinniu District, Chengdu 610036, Sichuan Province, China. tanglj2016@163.com
Key Words	Severe acute pancreatitis; Circular RNAs; N6-methyladenosine; MeRIP-seq; Epigenetic analysis
Core Tip	We identified transcriptome-wide map of N6-methyladenosine (m6A) circRNAs and determined their biological significance and potential mechanisms in severe acute pancreatitis (SAP). The main findings were: (1) Function analysis found that circRNAs with differentially expressed m6A peaks were involved in the key process of SAP; (2) m6A may affect the interplays of circRNAs and microRNAs to participate in the pathogenesis of SAP; and (3) Demethylase alkylation repair homolog 5 may play key roles in dynamic process of m6A to downregulate the total m6A level of circRNAs in SAP. We provided novel insights to explore the possible pathophysiological mechanism of SAP and seek new potential therapeutic targets.
Publish Date	2021-11-19 11:15
Citation	Wu J, Yuan XH, Jiang W, Lu YC, Huang QL, Yang Y, Qie HJ, Liu JT, Sun HY, Tang LJ. Genome-wide map of N6-methyladenosine circular RNAs identified in mice model of severe acute pancreatitis. World J Gastroenterol 2021; 27(43): 7530-7545
URL	https://www.wjgnet.com/1007-9327/full/v27/i43/7530.htm
DOI	https://dx.doi.org/10.3748/wjg.v27.i43.7530

Full Article (PDF)	WJG-27-7530.pdf
Full Article (Word)	WJG-27-7530.docx
The ARRIVE Guidelines	68269-The-ARRIVE-Guidelines-revision.pdf
Manuscript File	68269-Review-Filipodia.docx
Answering Reviewers	68269-Answering reviewers.pdf
Audio Core Tip	68269-Audio core tip.mp3
Biostatistics Review Certificate	68269-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	68269-Conflict-of-interest statement.pdf
Copyright License Agreement	68269-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	68269-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	68269-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	68269-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	68269-Language certificate.pdf
Supplementary Material	68269-Supplementary material.pdf
Peer-review Report	68269-Peer-review(s).pdf
Scientific Misconduct Check	68269-Bing-Wu YXJ-2.jpg
Scientific Editor Work List	68269-Scientific editor work list.pdf