Publication Name	World Journal of Hepatology
Manuscript ID	6829
Country	Italy

Received	2013-11-01 11:32
Peer-Review Started	2013-11-04 08:03
To Make the First Decision	2013-12-02 11:43
Return for Revision	2013-12-04 09:30
Revised
Second Decision	2014-01-20 08:54
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-01-20 10:03
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-03-03 03:05
Typeset the Manuscript	2014-05-08 20:34
Publish the Manuscript Online	2014-05-20 15:05

ISSN	1948-5182 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Physiology
Manuscript Type	Review
Article Title	Lipid lowering effects of iodothyronines: In vivo and in vitro studies on rat liver
Manuscript Source	Invited Manuscript
All Author List	Laura Vergani
Funding Agency and Grant Number
Corresponding Author	Laura Vergani, PhD, Assistant Professor, Dipartimento di Scienze della Terra, dell’Ambiente e della Vita, Università degli Studi di Genova, DISTAV, Corso Europa 26, 16132 Genova, Italy. laura.vergani@unige.it
Key Words	Iodothyronines; Liver steatosis; Lipid metabolism; Non-alcoholic fatty liver disease; Hepatocytes
Core Tip	This review summarizes the recent insights about the mechanisms underlying the lipid lowering action of iodothyronines. In the last decades, extensive studies investigated the possible use of iodothyronines in the treatment of obesity and dysmetabolic syndromes. Since the pharmacological use of thyroid hormones has found severe limitations because of their thyrotoxic effects, the identification of iodothyronines retaining anti-obesity and hypolipemic efficacies, while being devoid of thyrotoxicity, gained great interest. The review discusses the recent studies employing both in vivo and in vitro models of hepatosteatosis, with particular attention to the in vitro studies demonstrating the direct anti-steatotic effect of iodothyronines.
Publish Date	2014-05-20 15:05
Citation	Vergani L. Lipid lowering effects of iodothyronines: In vivo and in vitro studies on rat liver. World J Hepatol 2014; 6(4): 169-177
URL	http://www.wjgnet.com/1948-5182/full/v6/i4/169.htm
DOI	http://dx.doi.org/10.4254/wjh.v6.i4.169

Full Article (PDF)	WJH-6-169.pdf
Full Article (Word)	WJH-6-169.doc
Manuscript File	6829-Review.docx
Answering Reviewers	6829-Answering reviewers.pdf
Copyright License Agreement	6829-Copyright assignment.pdf
Peer-review Report	6829-Peer review(s).pdf
Scientific Editor Work List	6829-Scientific editor work list.doc