Publication Name	World Journal of Gastroenterology
Manuscript ID	6830
Country	China

Received	2013-10-29 12:40
Peer-Review Started	2013-10-29 17:38
First Decision by Editorial Office Director
Return for Revision	2013-12-20 13:34
Revised	2014-02-13 18:09
Publication Fee Transferred
Second Decision by Editor	2014-04-09 09:18
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-04-09 10:58
Articles in Press	2014-05-23 10:10
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-08-20 10:42
Publish the Manuscript Online	2014-08-20 18:38

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Novel therapeutic targets for pancreatic cancer
Manuscript Source	Invited Manuscript
All Author List	Shing-Chun Tang and Yang-Chao Chen
Funding Agency and Grant Number
Corresponding Author	Yang-Chao Chen, Professor, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China. frankch@cuhk.edu.hk
Key Words	Pancreatic cancer; CTHRC1; RAC1; RalGEF-RAl; Notch Signaling; Nodal/Activin Signaling; NDRG1; Hypoxic condition; DR5; PAR2; HER3; IAP; Non-coding RNA; HDAC; BMI1; EZH2; Pancreatic cancer stem cell; Tumour microenvironment
Core Tip	Some of the targets discussed here have been discovered to enhance the effectiveness of gemcitabine upon co-administration of the corresponding agents, for instance, hyaluronidase can deplete hyaluronan in stromal region to enhance gemcitabine delivery. Besides, some signaling molecules, e.g., RalGEF-RAl, Rac1, and PAR2 are being targeted to suppress metastasis. Tumour proliferation is limited upon DR5 activated apoptosis and others promising therapeutic areas like epigenetic modifiers; IAP, miR, lncRNA, and cancer stem cells-tumour microenvironment will also be discussed.
Publish Date	2014-08-20 18:38
Citation	Tang SC, Chen YC. Novel therapeutic targets for pancreatic cancer. World J Gastroenterol 2014; 20(31): 10825-10844
URL	http://www.wjgnet.com/1007-9327/full/v20/i31/10825.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i31.10825

Full Article (PDF)	WJG-20-10825.pdf
Full Article (Word)	WJG-20-10825.doc
Manuscript File	6830-Review.docx
Answering Reviewers	6830-Answering reviewers.pdf
Copyright License Agreement	6830-Copyright assignment.pdf
Peer-review Report	6830-Peer review(s).pdf
Scientific Editor Work List	6830-Scientific editor work list.doc