Publication Name	World Journal of Hepatology
Manuscript ID	68324
Country	Türkiye

Received	2021-05-18 19:41
Peer-Review Started	2021-05-18 19:44
To Make the First Decision
Return for Revision	2021-06-15 18:19
Revised	2021-06-23 18:12
Second Decision	2021-10-27 09:17
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-10-27 21:23
Articles in Press	2021-10-27 21:23
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-10-17 23:43
Typeset the Manuscript	2021-12-13 08:56
Publish the Manuscript Online	2021-12-27 05:24

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Infectious Diseases
Manuscript Type	Minireviews
Article Title	COVID-19 and the liver: A brief and core review
Manuscript Source	Invited Manuscript
All Author List	Bircan Kayaaslan and Rahmet Guner
ORCID	Author(s) ORCID Number Bircan Kayaaslan http://orcid.org/0000-0001-5225-8319 Rahmet Guner http://orcid.org/0000-0002-1029-1185
Funding Agency and Grant Number
Corresponding Author	Bircan Kayaaslan, MD, Associate Professor, Department of Infectious Disease and Clinical Microbiology, Ankara City Hospital, Ankara Yildirim Beyazit University, No. 1 Bilkent street, Çankaya District, Ankara 06800, Türkiye. drbican@gmail.com
Key Words	COVID-19; SARS-CoV-2; Liver injury; Liver dysfunction; Chronic liver disease; Pathophysiology
Core Tip	The study evaluated the incidence of liver injury in coronavirus disease 2019 (COVID-19) patients and its impact on clinical outcomes and pathophysiological mechanism of liver injury. More than one-fourth of COVID-19 patients had suffered from liver injury, mostly a mild-to-moderate liver dysfunction. Liver involvement is independently associated with adverse clinical outcomes. Direct viral cytotoxic effect, complications of the disease, and drugs used in the treatments are the pathophysiological mechanisms suggested for liver injury. However, the exact mechanism was not clearly explained. The actual cause should be carefully investigated in the presence of abnormal liver function tests, and appropriate treatments provided for possible factors.
Publish Date	2021-12-27 05:24
Citation	Kayaaslan B, Guner R. COVID-19 and the liver: A brief and core review. World J Hepatol 2021; 13(12): 2013-2023
URL	https://www.wjgnet.com/1948-5182/full/v13/i12/2013.htm
DOI	https://dx.doi.org/10.4254/wjh.v13.i12.2013

Full Article (PDF)	WJH-13-2013.pdf
Full Article (Word)	WJH-13-2013.docx
Manuscript File	68324_Auto_Edited-CKL-Filipodia.docx
Answering Reviewers	68324-Answering reviewers.pdf
Audio Core Tip	68324-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	68324-Conflict-of-interest statement.pdf
Copyright License Agreement	68324-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	68324-Language certificate.pdf
Peer-review Report	68324-Peer-review(s).pdf
Scientific Misconduct Check	68324-Bing-Gao CC-1.jpg
Scientific Misconduct Check	68324-Bing-Chang KL-2.jpg
Scientific Editor Work List	68324-Scientific editor work list.pdf
CrossCheck Report	68324-CrossCheck report.pdf