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Articles Published Processes
1/11/2022 12:11:23 AM | Browse: 1078 | Download: 2965
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Received |
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2021-05-19 22:28 |
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Peer-Review Started |
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2021-05-19 22:32 |
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First Decision by Editorial Office Director |
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2021-06-16 00:08 |
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Return for Revision |
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2021-06-16 00:08 |
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Revised |
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2021-06-30 01:40 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2021-12-06 03:29 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2021-12-08 06:00 |
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Articles in Press |
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2021-12-08 06:00 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-12-31 04:26 |
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Publish the Manuscript Online |
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2022-01-11 00:11 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Hydrogen-rich water exerts anti-tumor effects comparable to 5-fluorouracil in a colorectal cancer xenograft model
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Fereshteh Asgharzadeh, Alex Tarnava, Asma Mostafapour, Majid Khazaei and Tyler W LeBaron |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| HRW Natural Health Products Inc. |
dba Drink HRW |
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| Corresponding Author |
Tyler W LeBaron, BSc, MSc, N/A, Director, Director, Instructor, N/A, N/A, Research Scientist, Centre of Experimental Medicine, Institute for Heart Research Slovak Academy of Sciences, Dúbravská cesta 9, 841 04 Bratislava, Slovak Republic, Bratislava 984104 , Slovakia. lebaront@molecularhydrogeninstitute.com |
| Key Words |
Colorectal cancer; Molecular hydrogen; 5-fluorouracil; Oxidative stress; Antioxidants; Inflammation |
| Core Tip |
Colorectal cancer is a leading cause of death and is often treated with the chemotherapy drug, 5-fluorouracil (5-FU), which has some unwanted side effects. Molecular hydrogen (H2 gas) has antioxidant, anti-inflammatory, and anti-cancer effects. H2 gas can be dissolved in water to make hydrogen-rich water (HRW). The effects of HRW, 5-FU and the combination of HRW and 5-FU in a colorectal-cancer mouse model were examined. HRW and 5-FU decreased tumor size and weight with the combination being the most effective. In contrast to 5-FU, HRW attenuated oxidative stress and improved antioxidant activity. |
| Publish Date |
2022-01-11 00:11 |
| Citation |
Asgharzadeh F, Tarnava A, Mostafapour A, Khazaei M, LeBaron TW. Hydrogen-rich water exerts anti-tumor effects comparable to 5-fluorouracil in a colorectal cancer xenograft model. World J Gastrointest Oncol 2022; 14(1): 242-252
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| URL |
https://www.wjgnet.com/1948-5204/full/v14/i1/242.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v14.i1.242 |
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