Publication Name	World Journal of Gastroenterology
Manuscript ID	6837
Country	Italy

Received	2013-10-29 13:09
Peer-Review Started	2013-10-29 18:11
To Make the First Decision	2013-12-03 18:48
Return for Revision	2013-12-04 19:08
Revised	2014-01-08 22:33
Second Decision	2014-03-13 13:51
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-03-13 16:44
Articles in Press	2014-05-23 11:27
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-03-26 00:31
Typeset the Manuscript	2014-06-12 08:50
Publish the Manuscript Online	2014-06-27 10:37

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Virology
Manuscript Type	Autobiography
Article Title	Enigmatic origin of hepatitis B virus: An ancient travelling companion or a recent encounter?
Manuscript Source	Invited Manuscript
All Author List	Gianguglielmo Zehender, Erika Ebranati, Elena Gabanelli, Chiara Sorrentino, Alessandra Lo Presti, Elisabetta Tanzi, Massimo Ciccozzi and Massimo Galli
Funding Agency and Grant Number
Corresponding Author	Gianguglielmo Zehender, PhD, Assistant Professor, L. Sacco Department of Biomedical and Clinical Sciences, University of Milan, Via GB Grassi 74, 20157 Milano, Italy. gianguglielmo.zehender@unimi.it
Key Words	Hepatitis B virus genotypes and subgenotypes; Phylogeography; Population dynamics and epidemics; Molecular epidemiology; Hepatitis B virus phylodynamics
Core Tip	This review describes the main evidence concerning the global phylodynamics and phylogeography of hepatitis B virus (HBV) genotypes and subgenotypes, concentrating particularly on the ubiquitous A and D, and the more restricted E and F genotypes. The lack of consensus on the HBV evolutionary rate make it difficult to reconstruct the timescale of the virus origin. In order to reconcile the possibility of a long evolution and the high evolutionary rate in recent populations, we propose the hypothesis that HBV evolutionary rates are time dependent, and are influenced by the different population dynamics of the viral genotypes.
Publish Date	2014-06-27 10:37
Citation	Zehender G, Ebranati E , Gabanelli E, Sorrentino C, Lo Presti A, Tanzi E, Ciccozzi M, Galli M. Enigmatic origin of hepatitis B virus: An ancient travelling companion or a recent encounter? World J Gastroenterol 2014; 20(24): 7622-7634
URL	http://www.wjgnet.com/1007-9327/full/v20/i24/7622.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i24.7622

Full Article (PDF)	WJG-20-7622.pdf
Full Article (Word)	WJG-20-7622.doc
Manuscript File	6837-Review.docx
Answering Reviewers	6837-Answering reviewers.pdf
Copyright License Agreement	6837-Copyright assignment.pdf
Peer-review Report	6837-Peer reviewer(s).pdf
Scientific Editor Work List	6837-Scientific editor work list.doc