Publication Name	World Journal of Gastroenterology
Manuscript ID	6839
Country	China

Received	2013-10-29 13:21
Peer-Review Started	2013-10-29 18:10
To Make the First Decision	2013-12-16 17:40
Return for Revision	2013-11-22 16:17
Revised	2013-11-28 09:53
Second Decision	2014-03-10 15:10
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-03-10 17:02
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-03-30 17:53
Typeset the Manuscript	2014-05-07 09:32
Publish the Manuscript Online	2014-06-06 16:55

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Virus-related liver cirrhosis: Molecular basis and therapeutic options
Manuscript Source	Invited Manuscript
All Author List	Ji Lin, Jian-Feng Wu, Qi Zhang, Hong-Wei Zhang and Guang-Wen Cao
Funding Agency and Grant Number
Corresponding Author	Guang-Wen Cao, MD, PhD, Professor, Chairman, Department of Epidemiology, Second Military Medical University, 800 Xiangyin Rd., Shanghai 200433, China. gcao@smmu.edu.cn
Key Words	Liver cirrhosis; Hepatitis B virus; Hepatitis C virus; Evolution; Immune cells; Signaling pathway; Hepatic stellate cells; Antiviral therapy
Core Tip	Hepatic inflammation caused by viral infections contributes to the inflammation-necrosis-regeneration process, ultimately cirrhosis. Immune selection of some hepatitis B virus mutations in the evolution towards cirrhosis seems different from that towards hepatocellular carcinoma. Hepatic stellate cells and macrophages are important for the fibrogenesis. Antiviral treatment is generally effective in reducing the morbidity of decompensated cirrhosis. The standard of care for the treatment of hepatitis C virus-related cirrhosis with pegylated interferon-? and ribavirin should consider the genotypes of IL-28B. Stem cell-based therapy can be an option for the treatment of decompensated cirrhosis patients who fail to respond to antiviral treatment.
Publish Date	2014-06-06 16:55
Citation	Lin J, Wu JF, Zhang Q, Zhang HW, Cao GW. Virus-related liver cirrhosis: Molecular basis and therapeutic options. World J Gastroenterol 2014; 20(21): 6457-6469
URL	http://www.wjgnet.com/1007-9327/full/v20/i21/6457.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i21.6457

Full Article (PDF)	WJG-20-6457.pdf
Full Article (Word)	WJG-20-6457.doc
Manuscript File	6839-Review.doc
Answering Reviewers	6839-Answering reviewers.pdf
Copyright License Agreement	6839-Copyright assignment.pdf
Peer-review Report	6839-Peer review(s).pdf
Scientific Editor Work List	6839-Scientific editor work list.doc