Publication Name	World Journal of Gastroenterology
Manuscript ID	6843
Country	Taiwan

Received	2013-10-29 15:01
Peer-Review Started	2013-10-30 21:47
To Make the First Decision	2013-11-21 19:02
Return for Revision	2014-04-28 14:36
Revised	2014-05-12 16:19
Second Decision	2014-06-23 10:02
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-06-23 10:26
Articles in Press	2014-06-23 10:36
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-07-08 10:57
Typeset the Manuscript	2014-10-19 16:58
Publish the Manuscript Online	2014-10-29 19:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Virology
Manuscript Type	Topic Highlights
Article Title	Hepatitis D virus infection, replication and cross-talk with the hepatitis B virus
Manuscript Source	Invited Manuscript
All Author List	Chi-Ruei Huang and Szecheng John Lo
Funding Agency and Grant Number	Funding Agency Grant Number Chang Gung Memorial Hospital CMRPD-1C0811 National Science Council and the National Health Research Institute to Lo SJ
Corresponding Author	Szecheng John Lo, PhD, Department of Biomedical Sciences, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Road, Taoyuan 333, Taiwan. losj@mail.cgu.edu.tw
Key Words	Hepatitis B virus; Hepatitis D virus; Posttranslational modification; Endoplasmic reticulum stress; Nuclear export
Core Tip	Hepatitis D virus (HDV) is a defective virus that depends on hepatitis B virus (HBV) to supply envelope proteins (HBsAgs) for assembling a new virion. The association of the clinical severity of hepatitis with HDV genotypes (HDV-1 to 8) has been reported, but the mechanism is unknown. Whether the combinations of HBV genotypes (A to H) with HDV genotypes cause varying clinical outcomes remains to be explored. This review focuses on HDV replication, the cross-talk between HDV and HBV, and the endoplasmic reticulum (ER) stress induced by HBsAgs in the ER which results in the promotion of large delta antigen export from the nucleus to interact with HBsAgs.
Publish Date	2014-10-29 19:34
Citation	Huang CR, Lo SJ. Hepatitis D virus infection, replication and cross-talk with the hepatitis B virus. World J Gastroenterol 2014; 20(40): 14589-14597
URL	http://www.wjgnet.com/1007-9327/full/v20/i40/14589.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i40.14589

Full Article (PDF)	WJG-20-14589.pdf
Full Article (Word)	WJG-20-14589.doc
Manuscript File	6843-Review.docx
Answering Reviewers	6843-Answering reviewers.pdf
Copyright License Agreement	6843-Copyright assignment.pdf
Peer-review Report	6843-Peer review.pdf
Scientific Misconduct Check	6843-CorssCheck.jpg
Scientific Editor Work List	6843-Scientific editor work list.pdf