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Articles Published Processes
11/19/2021 11:15:33 AM | Browse: 524 | Download: 1362
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Received |
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2021-05-23 15:40 |
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Peer-Review Started |
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2021-05-23 15:43 |
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To Make the First Decision |
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Return for Revision |
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2021-06-12 02:24 |
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Revised |
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2021-07-19 11:04 |
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Second Decision |
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2021-10-26 07:59 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-10-27 03:04 |
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Articles in Press |
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2021-10-27 03:04 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-10-06 11:14 |
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Typeset the Manuscript |
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2021-11-16 14:16 |
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Publish the Manuscript Online |
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2021-11-19 11:15 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Survivin-positive circulating tumor cells as a marker for metastasis of hepatocellular carcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jing Yu, Zhan Wang, Hua Zhang, Yi Wang and Dong-Qing Li |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of China |
81772839 |
| Health and Family Planning Commission Foundation of Hubei Province |
WJ2019H194 |
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| Corresponding Author |
Jing Yu, PhD, Associate Chief Technician, Doctor, Doctor, Blood Transfusion Department, Wuhan Chinese and Western Medicine Hospital, No. 215 Zhongshan road, Wuhan 430022, Hubei Province, China. yujings9774@sina.com.cn |
| Key Words |
Survivin; Circulating tumor cells; Hepatocellular carcinoma; Prognosis; Metastasis |
| Core Tip |
This study first analyzed the circulating tumor cell (CTC)-survivin positive in patients with hepatocellular carcinoma (HCC). The signal levels of survivin expression in different CTCs were significant different. The rates of moderate and high signal in the mesenchymal and hybrid CTCs were significant more than those in the epithelial CTCs. Survivin overexpression induces HCC cells proliferation, invasive ability and reduce apoptosis. The expression of survivin in mesenchymal CTCs (mCTCs) in liver cancer is associated with metastasis and detection of survivin positivity in mCTCs may have a potential value in early detection of tumor metastases and prognostic evaluation. |
| Publish Date |
2021-11-19 11:15 |
| Citation |
Yu J, Wang Z, Zhang H, Wang Y, Li DQ. Survivin-positive circulating tumor cells as a marker of the metastasis of hepatocellular carcinoma. World J Gastroenterol 2021; 27(43): 7546-7562 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i43/7546.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i43.7546 |
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