Publication Name	World Journal of Hepatology
Manuscript ID	68457
Country	Italy

Received	2021-05-27 10:24
Peer-Review Started	2021-05-27 10:27
To Make the First Decision
Return for Revision	2021-07-06 02:00
Revised	2021-07-21 09:55
Second Decision	2022-01-24 03:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-01-25 03:24
Articles in Press	2022-01-25 03:24
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-01-21 10:42
Typeset the Manuscript	2022-02-15 09:28
Publish the Manuscript Online	2022-02-22 09:25

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Immunomodulation by probiotics and prebiotics in hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Edda Russo, Camila Fiorindi, Francesco Giudici and Amedeo Amedei
ORCID	Author(s) ORCID Number Edda Russo http://orcid.org/0000-0003-3141-1091 Camila Fiorindi http://orcid.org/0000-0003-1387-0446 Francesco Giudici http://orcid.org/0000-0002-6879-5685 Amedeo Amedei http://orcid.org/0000-0002-6797-9343
Funding Agency and Grant Number	Funding Agency Grant Number ECCO 2021
Corresponding Author	Amedeo Amedei, PhD, Professor, Department of Experimental and Clinical Medicine, University of Florence, Complesso Cubo, Viale Pieraccini 6, Florence 50134, Tuscany, Italy. amedeo.amedei@unifi.it
Key Words	Hepatocellular carcinoma; Gut microbiota; Probiotics; Prebiotics; Gut-liver axis; Immunomodulation
Core Tip	In patients with chronic liver disease and cirrhosis, hepatocellular carcinoma (HCC) is the most common primary malignancy. Recent attention has been paid to the involvement of the gut-liver axis (GLA) in HCC pathogenesis. This review explores the potential for new treatment options as a result of novel insights into the processes by which microbiota immunomodulation, represented by probiotics and prebiotics, affects HCC through the GLA.
Publish Date	2022-02-22 09:25
Citation	Russo E, Fiorindi C, Giudici F, Amedei A. Immunomodulation by probiotics and prebiotics in hepatocellular carcinoma. World J Hepatol 2022; 14(2): 372-385
URL	https://www.wjgnet.com/1948-5182/full/v14/i2/372.htm
DOI	https://dx.doi.org/10.4254/wjh.v14.i2.372

Full Article (PDF)	WJH-14-372.pdf
Full Article (Word)	WJH-14-372.docx
Manuscript File	68457_Auto_Edited-JJW-Webster J.docx
Answering Reviewers	68457-Answering reviewers.pdf
Audio Core Tip	68457-Audio core tip.mp4
Conflict-of-Interest Disclosure Form	68457-Conflict-of-interest statement.pdf
Copyright License Agreement	68457-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	68457-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	68457-Language certificate.pdf
Peer-review Report	68457-Peer-review(s).pdf
Scientific Misconduct Check	68457-Bing-Wang JJ-2.png
Scientific Editor Work List	68457-Scientific editor work list.pdf
CrossCheck Report	68457-CrossCheck report.pdf