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Articles Published Processes
11/24/2021 9:54:22 AM | Browse: 473 | Download: 1301
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Received |
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2021-05-24 17:26 |
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Peer-Review Started |
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2021-05-24 17:27 |
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First Decision by Editorial Office Director |
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2021-06-15 18:18 |
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Return for Revision |
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2021-06-15 18:18 |
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Revised |
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2021-06-30 11:08 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2021-08-17 03:30 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2021-08-18 06:41 |
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Articles in Press |
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2021-08-18 06:41 |
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Edit the Manuscript by Language Editor |
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2021-08-31 04:03 |
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Typeset the Manuscript |
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2021-11-19 00:40 |
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Publish the Manuscript Online |
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2021-11-24 09:54 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Mitochondrial hepatopathy: Respiratory chain disorders- ‘breathing in and out of the liver’
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Amrit Gopan and Moinak S Sarma |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Moinak S Sarma, N/A, Associate Professor, DM, Department of Pediatric Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Rae Bareilly Road, Lucknow 226014, India. moinaksen@yahoo.com |
| Key Words |
Mitochondrial hepatopathy; Respiratory chain defects; Maternal inheritance; Neonatal liver failure; DNA depletion syndrome; Pearson syndrome |
| Core Tip |
Liver disease with multi-system involvement should arouse the suspicion for mitochondrial respiratory chain hepatopathies. These disorders are predominantly autosomal recessive with some having a maternal inheritance. Presence of lactic acidosis without hypoglycemia is an important clue. A tiered evaluation yields the most with final step being a genetic and enzyme analysis from tissue of interest. Treatment is largely supportive with blood transfusions, correction of acidosis, shock, providing cofactors and salvage therapies, with liver transplantation in a select group. A Periodic follow-up is mandatory for monitoring evolution of disease including “migration” to other systems. |
| Publish Date |
2021-11-24 09:54 |
| Citation |
Gopan A, Sarma MS. Mitochondrial hepatopathy: Respiratory chain disorders- ‘breathing in and out of the liver’. World J Hepatol 2021; 13(11): 1707-1726 |
| URL |
https://www.wjgnet.com/1948-5182/full/v13/i11/1707.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v13.i11.1707 |
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